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Neuromodulation

Standard TMS for Depression

N/A
Waitlist Available
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Men and women, ages 18 years and up
* English speaking
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 45 minutes
Awards & highlights

Summary

The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans. The goal is to use this understanding to develop new, personalized brain stimulation. The investigators evaluate brain changes from different types of transcranial magnetic brain stimulation (TMS).

Eligible Conditions
  • Depression

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~45 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 45 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Transcranial Magnetic Stimulation (TMS) / Electroencephalography (EEG) change

Trial Design

2Treatment groups
Active Control
Group I: Standard TMSActive Control1 Intervention
A series of standard TMS protocols will be delivered to determine target engagement compared to seTMS. TMS will be delivered using neuro-navigation based on participant's own MRI images. Intensity will be set to 120% of the participant's motor threshold. Participants will be monitored during the session for adverse events and/or side effects.
Group II: Sensory-entrained TMS (seTMS)Active Control1 Intervention
Sensory entrained TMS (seTMS) is a combination of music and TMS to align brain oscillations and enhance the effects of TMS. seTMS will be delivered to determine target engagement to noninvasive seTMS brain stimulation compared to standard TMS. TMS will be delivered using neuro-navigation based on participant's own MRI images. Intensity will be set to 120% of the participant's motor threshold. Participants will be monitored during the session for adverse events and/or side effects.

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Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,432 Previous Clinical Trials
17,465,081 Total Patients Enrolled
109 Trials studying Depression
94,132 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,840 Previous Clinical Trials
2,712,722 Total Patients Enrolled
680 Trials studying Depression
257,869 Patients Enrolled for Depression
~167 spots leftby Oct 2029
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