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Behavioural Intervention

Daily Incremental Vestibulo-ocular Reflex Adaptation (D-IVA-GSE) for Multiple Sclerosis (DIIVA-MS Trial)

N/A
Waitlist Available
Led By Colin Grove, PT, MS, DPT, PhD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Neurologist-confirmed diagnosis of primary progressive or relapsing and remitting MS per the 2017 Revision of the McDonald Criteria and the Magnetic Resonance Imaging in MS
* Fluent in speaking and understanding English
Timeline
Screening 3 weeks
Treatment Varies
Follow Up weeks 1,4, 7, and 18
Awards & highlights

Summary

The study aims to study the effects of a novel treatment for vestibular symptoms in people with multiple sclerosis. The main objective is to determine whether daily personalized gaze stabilization training is more beneficial than intermittent gaze stability training in people with multiple sclerosis.

Eligible Conditions
  • Multiple Sclerosis

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~weeks 1,4, 7, and 18
This trial's timeline: 3 weeks for screening, Varies for treatment, and weeks 1,4, 7, and 18 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Composite VOR gain (cVOR gain)
Secondary study objectives
Activities-specific Balance Confidence Scale Average Score
Balance Evaluation Systems Test Total Score
Best Corrected Dynamic Visual Acuity (During Head Movements)
+6 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Intermittent incremental vestibulo-ocular Reflex Adaptation (I-IVA-GSE)Experimental Treatment1 Intervention
The I-IVA-GSE group will perform two, 15-minute IVA-GSE sessions (30 minutes total), three days per week, with at least one day between each exercise day.
Group II: Daily Incremental Vestibulo-ocular Reflex Adaptation (D-IVA-GSE)Experimental Treatment1 Intervention
The dosages of the D-IVA-GSE and I-IVA-GSE are based on the FITT principle of exercise prescription (frequency, intensity, time, and type). The D-IVA-GSE group will perform two, 15- minute GSE sessions (30-minutes total per day), seven days per week.

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Who is running the clinical trial?

National Multiple Sclerosis SocietyOTHER
97 Previous Clinical Trials
9,522 Total Patients Enrolled
95 Trials studying Multiple Sclerosis
9,168 Patients Enrolled for Multiple Sclerosis
Emory UniversityLead Sponsor
1,679 Previous Clinical Trials
2,579,903 Total Patients Enrolled
2 Trials studying Multiple Sclerosis
241 Patients Enrolled for Multiple Sclerosis
Colin Grove, PT, MS, DPT, PhDPrincipal InvestigatorEmory University
~92 spots leftby Sep 2026
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