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Herbal Supplement

Centella Asiatica for Blood Vessel Health in Older Adults

N/A
Waitlist Available
Research Sponsored by National University of Natural Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 50 through 85, male or female
Be older than 18 years old
Must not have
Recent/recurring history of severe life-threatening medical conditions (e.g. cancer, except non-melanoma skin cancers)
Active major infectious disease (e.g. pneumonia)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 4

Summary

This trial aims to investigate how a dietary supplement with centella asiatica affects blood vessel function in older adults.

Who is the study for?
This trial is for English-speaking adults aged 50-85 who can consent and follow the study plan. It's not for those with severe medical conditions, infectious diseases, on sedatives or blood pressure meds, pregnant/nursing women, heavy drinkers/substance users, or people with certain heart/CNS/liver disorders.
What is being tested?
The study tests if a dietary supplement containing Centella Asiatica improves blood vessel function in older adults. Participants will either receive the actual supplement or a placebo to compare effects.
What are the potential side effects?
Potential side effects are not specified in the provided information but could include typical reactions to new supplements such as digestive discomfort, allergic reactions, or headaches.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 50 and 85 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have not had a severe life-threatening illness recently, except for non-melanoma skin cancers.
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I do not have any active major infections like pneumonia.
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I am currently taking sedatives or sleep aids.
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I am currently taking medication for erectile dysfunction.
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I have a history of heart issues, including heart attack or heart failure.
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I have a history of major brain disorders like stroke or Parkinson's.
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I have a history of liver disease.
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I am currently taking blood thinners.
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I regularly use NSAIDs more than three times a week for over three months.
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I am currently taking medication for low blood sugar, like Metformin.
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I have open skin rashes or sores that could affect sensor placement.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Endothelial Function
Secondary study objectives
Blood Pressure
Body Mass Index (BMI)
Heart Rate Variability (HRV)
Other study objectives
Adherence
Alanine aminotransferase
Albumin
+16 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Centlla AsiaticaExperimental Treatment1 Intervention
250 mg/day (1 capsules) for week 1. 500 mg/day (2 capsules) for week 2. 750 mg/day (3 capsules) for week 3. 1000 mg/ day (4 capsules) for week 4.
Group II: PlaceboPlacebo Group1 Intervention
Matched number of capsules per week. Capsules will contain microcrystalline cellulose.

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Who is running the clinical trial?

National University of Natural MedicineLead Sponsor
31 Previous Clinical Trials
1,249 Total Patients Enrolled
~20 spots leftby Sep 2025
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