← Back to Search

Procedure

TMS for Temporal Lobe Epilepsy

N/A

Waitlist Available

Led By Joel Voss, PhD

Research Sponsored by University of Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Native English speakers

Age 18+ years old

Must not have

Children under the age of 18 years

Diagnosis of neurological illness other than MTLE

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from the baseline session to 30 days following the post-treatment sessions

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to study how the hippocampus functions in people with mesial temporal lobe epilepsy (MTLE) and if using transcranial magnetic stimulation (TMS) on the hippocampal

Who is the study for?

This trial is for individuals with a primary diagnosis of mesial temporal lobe epilepsy (MTLE). Participants should be able to undergo neurocognitive testing, fMRI scans, and EEG monitoring. They must also keep a seizure diary for one month. Specific inclusion and exclusion criteria details are not provided.

What is being tested?

The study tests if transcranial magnetic stimulation (TMS) can affect memory performance and epileptic activity in MTLE patients by targeting the hippocampal network. It involves baseline assessments, TMS sessions, and follow-up evaluations to measure changes in memory task performance and brain activity.

What are the potential side effects?

Potential side effects of TMS may include discomfort at the stimulation site, headache, lightheadedness, or seizures; however specific side effects related to this trial's protocol are not detailed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am a native English speaker.

Select...

I am 18 years old or older.

Select...

My vision is normal or corrected to normal.

Select...

I have been diagnosed with medication-resistant temporal lobe epilepsy.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am under 18 years old.

Select...

I have a neurological condition that is not mesial temporal lobe epilepsy.

Select...

I am not on any cognition-impairing drugs except for anticonvulsants for MTLE.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the memory task is administered at baseline and 1 day after the last stimulation session. recall will be measured approximately 15 minutes after seeing the word pairs.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the memory task is administered at baseline and 1 day after the last stimulation session. recall will be measured approximately 15 minutes after seeing the word pairs.

This trial's timeline: 3 weeks for screening, Varies for treatment, and the memory task is administered at baseline and 1 day after the last stimulation session. recall will be measured approximately 15 minutes after seeing the word pairs. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Epileptic activity (IEDs)

Secondary study objectives

Memory task performance

Seizure frequency reported in seizure diary

fMRI connectivity of the hippocampal network

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Experiment 1Experimental Treatment1 Intervention

Subjects will be tested for baseline performance on a memory task while in an MRI scanner and with scalp EEG. Subjects will then receive multiple sessions, of repetitive transcranial magnetic stimulation. Post-treatment, baseline assessments will be repeated. Overall study period per subject: 2 months

0 / 7Eligibility criteria met