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Functional MRI for Brain Tumor Surgery Assessment
N/A
Recruiting
Led By Ho-Ling A Liu
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 weeks
Awards & highlights
No Placebo-Only Group
Summary
This trial looks at how well two types of MRI work in measuring language function before and after surgery for brain tumors.
Who is the study for?
This trial is for right-handed English speakers with a new brain mass suspected to be glioma, located near critical language areas. They must not have had prior neurologic diseases or treatments affecting cognition and should agree to pre- and post-surgery neuropsychological tests.
What is being tested?
The study measures the impact of surgery on language functions in glioma patients using resting-state functional MRI and cerebrovascular reactivity MRI before and after their operations.
What are the potential side effects?
Since this trial involves non-invasive imaging techniques like MRI, side effects are minimal but may include discomfort from lying still during the scan or noise from the machine.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 6 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 weeks
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Detectability of language networks
Secondary study objectives
Changes in resting-state functional connectivity and neuropsychological outcomes
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Diagnostic (fMRI, CVR MRI, rs-fMRI)Experimental Treatment3 Interventions
Patients undergo standard of care fMRI, CVR MRI over 3 minutes, and rs-fMRI over 6 minutes 1 month before and within 6 weeks after standard of care surgery.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Functional Magnetic Resonance Imaging
2016
Completed Phase 4
~890
Magnetic Resonance Imaging
2017
Completed Phase 3
~1160
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Who is running the clinical trial?
M.D. Anderson Cancer CenterLead Sponsor
3,065 Previous Clinical Trials
1,802,218 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,917 Previous Clinical Trials
41,014,435 Total Patients Enrolled
Ho-Ling A LiuPrincipal InvestigatorM.D. Anderson Cancer Center
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You have received radiation therapy or chemotherapy in the past.You are right-handed.The tumor is in an area of your brain that is important for language.
Research Study Groups:
This trial has the following groups:- Group 1: Diagnostic (fMRI, CVR MRI, rs-fMRI)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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