Niagen® vs NAD+ for Healthy Aging

N/A

Waitlist Available

Research Sponsored by Franklin Health Research

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Any gender, aged 40+ (For the 5th arm, only males will be evaluated.)

Be older than 18 years old

Must not have

Current diagnosis of any seizure disorder, diabetes or insulin resistance, any kidney or liver disorder, heart disease, cancer, or Parkinson's disease

Existing usage of a NAD+ or NAD precursor supplement in any form

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, at 3 hours, and 24 hours post administration of intervention

Summary

"This trial is looking at how giving NR through an IV affects healthy adults. The first part of the study had four groups with 37 participants, while the second part focused on the active NR and N

Who is the study for?

This trial is for healthy adults aged 40+ who live within 100 miles of the study site and can follow all procedures. Women must use effective contraception. Excluded are those with recent COVID-19, new drugs or interventions, seizure disorders, diabetes, kidney/liver/heart diseases, cancer, Parkinson's disease, pregnancy/breastfeeding individuals or those on NAD+ supplements.

What is being tested?

The study tests the effects of IV Niagen® (nicotinamide riboside) versus NAD+ and an oral form of Niagen®, compared to a placebo in promoting healthy aging. The first part included all options with 37 participants; the second focuses only on active treatments for tolerability.

What are the potential side effects?

Potential side effects may include reactions at the injection site due to IV administration and any common side effects associated with nicotinamide riboside or NAD+, though specific side effect profiles are not provided.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 40 years or older. For the specific study part, I am male.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a current diagnosis of a seizure disorder, diabetes, kidney or liver disorder, heart disease, cancer, or Parkinson's disease.

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I am currently taking NAD+ or NAD precursor supplements.

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My weight has changed by more than 10% in the last 6 months.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediately before the intervention, immediately after the intervention, 3 and 6 hours post-intervention, and at the 24 hour visit.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediately before the intervention, immediately after the intervention, 3 and 6 hours post-intervention, and at the 24 hour visit.

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately before the intervention, immediately after the intervention, 3 and 6 hours post-intervention, and at the 24 hour visit. for reporting.