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Handgrip Test for Heart Function Assessment in Adults

N/A
Recruiting
Led By Satish R Raj, MD MSCI
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinical heart failure (HFrEF or HFpEF) for heart failure patients and no clinical heart failure for the non-heart failure participants.
Age 18 years or older
Must not have
On intravenous inotrope or pressor medications to maintain their cardiac function
Unable or unwilling to provide informed consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 day
Awards & highlights
No Placebo-Only Group

Summary

This trial will assess whether or not the "head capacity principle" can be used to assess left ventricular pump function in human adults, with or without heart failure.

Who is the study for?
This trial is for adults over 18 with heart failure, as well as those without it. Participants must be able to give informed consent and not be on IV medications like inotropes or pressors that help maintain heart function.
What is being tested?
The study tests new non-invasive methods to assess systemic circulation and left ventricular performance using a handgrip test. It involves one outpatient visit where subjects perform the grip test while monitored with EKG electrodes and blood pressure cuffs.
What are the potential side effects?
Since this trial uses non-invasive monitoring during a handgrip exercise, side effects are minimal but may include temporary discomfort from gripping or wearing the monitoring devices.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have heart failure or I do not have heart failure, depending on the study group I am in.
Select...
I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am on IV medication to support my heart function.
Select...
I cannot or do not want to give permission for treatment.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Head-Capacity Curve (HCC)
Secondary study objectives
Cardiac Power
Systemic Vascular Conductance (SVC)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: HFrEFExperimental Treatment1 Intervention
patients with heart failure with reduced ejection fraction
Group II: HFpEFExperimental Treatment1 Intervention
heart failure with preserved ejection fraction
Group III: ControlActive Control1 Intervention
healthy (no heart failure) control participants

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
809 Previous Clinical Trials
886,289 Total Patients Enrolled
13 Trials studying Heart Failure
6,286 Patients Enrolled for Heart Failure
Satish R Raj, MD MSCIPrincipal InvestigatorUniversity of Calgary
19 Previous Clinical Trials
1,326 Total Patients Enrolled

Media Library

handgrip test Clinical Trial Eligibility Overview. Trial Name: NCT04347655 — N/A
Heart Failure Research Study Groups: HFrEF, HFpEF, Control
Heart Failure Clinical Trial 2023: handgrip test Highlights & Side Effects. Trial Name: NCT04347655 — N/A
handgrip test 2023 Treatment Timeline for Medical Study. Trial Name: NCT04347655 — N/A
~25 spots leftby Dec 2025
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