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Resistance Exercise + Vinegar for Cognitive Impairment

N/A
Recruiting
Research Sponsored by Arizona State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Premenopausal (for those assigned female at birth)
Be between 18 and 65 years old
Must not have
Antibiotic use within the past three months
Presence of any gastrointestinal disorder such as irritable bowel syndrome, inflammatory bowel disease, Crohn's disease, diverticulitis/diverticulosis, etc.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Summary

"This trial explores how resistance exercise can benefit individuals with cognitive impairments by potentially modifying the microbiota-gut-brain axis. It aims to investigate the impact of acetic acid on the intestinal barrier and

Who is the study for?
This trial is for healthy, sedentary adults who can do moderate to vigorous exercise and have gym access. Participants must be premenopausal if assigned female at birth and available for lab visits. It's not for those with recent antibiotic use, any medical/psychiatric diseases, gastrointestinal disorders, pregnancy/breastfeeding, vegetarians or those on certain supplements.
What is being tested?
The study tests how resistance exercise combined with vinegar ingestion (either as a liquid or pill) affects biomarkers related to the gut-brain axis in healthy adults. The focus is on mood and cognitive functions potentially linked to intestinal health.
What are the potential side effects?
While specific side effects are not detailed here, typical reactions might include digestive discomfort from vinegar intake and muscle soreness from resistance exercises.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am premenopausal.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have taken antibiotics in the last 3 months.
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I have a gastrointestinal condition like IBS or Crohn's disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cognitive change
Depression
Lipopolysaccharide

Side effects data

From 2012 Phase 2 trial • 56 Patients • NCT00540722
38%
fatigue
7%
vomiting
7%
Rash maculo-papular
7%
peripheral sensory neuropathy
7%
constipation
5%
diarrhea
5%
anorexia
2%
Seizure
2%
lleus
2%
cardiac disorder other
2%
hypophosphatemia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Treatment (R-(-)-Gossypol Acetic Acid)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Liquid vinegarExperimental Treatment1 Intervention
2 tablespoons of liquid apple cider vinegar (5% acidity) diluted in one cup of water twice daily with meals providing 1.5g acetic acid.
Group II: Vinegar pillPlacebo Group1 Intervention
one apple cider vinegar tablet (0.022g acetic acid) daily.

Find a Location

Who is running the clinical trial?

Arizona State UniversityLead Sponsor
294 Previous Clinical Trials
107,400 Total Patients Enrolled
~6 spots leftby Oct 2024
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