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1 for Obstructive Sleep Apnea

N/A
Waitlist Available
Led By Mark H Sanders, MD
Research Sponsored by National Institute on Aging (NIA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome. The investigators hypothesize that the sleep fragmentation and intermittent sleep hypoxia which occur in OSAH patients promote oxidative stress and inflammation which in turn lead to insulin resistance, dyslipidemia, abnormal vascular reactivity and other processes which are consistent with the metabolic syndrome.

Eligible Conditions
  • Obstructive Sleep Apnea
  • Metabolic Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

5Treatment groups
Experimental Treatment
Active Control
Group I: 5Experimental Treatment1 Intervention
OSAH patients without chronic positive airway pressure therapy
Group II: 4Experimental Treatment1 Intervention
OSAH patients with chronic positive airway pressure therapy
Group III: 2Experimental Treatment1 Intervention
non-OSAH/overweight individuals without Metabolic Syndrome
Group IV: 1Experimental Treatment1 Intervention
non-OSAH/overweight individuals with the Metabolic Syndrome
Group V: 3Active Control1 Intervention
non-OSAH/normal weight without Metabolic Syndrome

Find a Location

Who is running the clinical trial?

National Institute on Aging (NIA)Lead Sponsor
1,783 Previous Clinical Trials
28,184,147 Total Patients Enrolled
University of PittsburghOTHER
1,783 Previous Clinical Trials
16,357,115 Total Patients Enrolled
Mark H Sanders, MDPrincipal InvestigatorUniversity of Pittsburgh
~3 spots leftby Nov 2025
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