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Cancer Vaccine

Blueberry + walking for Mild Cognitive Impairment

N/A
Waitlist Available
Led By David C Nieman, DrPH
Research Sponsored by Appalachian State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Score on the Montreal Cognitive Assessment (MoCA test) of 24.1-25.2 that indicates mild cognitive decline.
* Healthy, non-smoking male or female participants 65 to 85 years of age.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from pre-study to 6-weeks and 12-weeks
Awards & highlights

Summary

This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.

Eligible Conditions
  • Mild Cognitive Impairment

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from pre-study to 6-weeks and 12-weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from pre-study to 6-weeks and 12-weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cognition
Secondary study objectives
Gut microbiome
Maximal aerobic capacity
Urine blueberry metabolites

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Blueberry + walkingExperimental Treatment2 Interventions
Blueberry intake combined with walking exercise.
Group II: Blueberry + stretchingExperimental Treatment2 Interventions
Blueberry intake combined with stretching exercise.
Group III: Placebo + stretchingActive Control2 Interventions
Placebo intake combined with stretching exercise.
Group IV: Placebo + walkingActive Control2 Interventions
Placebo intake combined with walking exercise.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stretching
2019
N/A
~2330
Blueberry
2017
N/A
~210
Walking
2016
Completed Phase 2
~1550

Find a Location

Who is running the clinical trial?

Appalachian State UniversityLead Sponsor
43 Previous Clinical Trials
2,262 Total Patients Enrolled
David C Nieman, DrPHPrincipal InvestigatorAppalachian State Univ
15 Previous Clinical Trials
687 Total Patients Enrolled
~160 spots leftby Dec 2027
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