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Behavioural Intervention

Treadmill Training for Mild Cognitive Impairment and Alzheimer's Disease

N/A
Recruiting
Led By Trisha Kesar, PT, PhD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy Older Adults: No history of neurologic, musculoskeletal, or medical conditions affecting walking
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (pre-training), week 2 (post-training)
Awards & highlights

Summary

"This trial aims to study how Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) affect the ability to adapt while walking. Understanding this could help improve walking function in individuals with

Who is the study for?
This trial is for older adults who can walk without help and have been formally diagnosed with Mild Cognitive Impairment or Alzheimer's Disease by a neurologist. They should not have any medical conditions that affect walking, no recent hospitalizations, and must be able to perform study tasks.
What is being tested?
The study tests how well people with MCI or AD adapt their walking on a split-belt treadmill over five sessions. The goal is to understand the impact of these cognitive conditions on the ability to adjust walking patterns, which could lead to better exercise-based treatments.
What are the potential side effects?
While specific side effects are not detailed for this type of physical intervention, participants may experience fatigue or discomfort from the treadmill exercises. There might also be an increased risk of falls due to balance challenges during adaptation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have no health conditions that affect my ability to walk.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (pre-training), week 2 (post-training)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (pre-training), week 2 (post-training) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in 10-Meter Overground Walk Test
Change in 6-Minute Walk Test
Change in Adaptation Magnitude Assessed as Peak Step Length Symmetry
+2 more
Secondary study objectives
Change in De-adaptation Magnitude Assessed as Peak Step Length Symmetry
Change in De-adaptation Rate Assessed as the Number of Steps to Reach Step Symmetry
Change in Step Length
+2 more
Other study objectives
Change in Double-support Duration
Change in Executive Index Score (EIS)
Change in Falls History
+2 more

Trial Design

4Treatment groups
Experimental Treatment
Group I: Split-beltTreadmill-based Locomotor Adaptation in Older Adults with MCIExperimental Treatment1 Intervention
In Aim 3 of this study, older adults with mild cognitive impairment (MCI) complete 5 split-belt treadmill walking exercise sessions over a 2-week period.
Group II: Split-beltTreadmill-based Locomotor Adaptation in Older Adults with ADExperimental Treatment1 Intervention
In Aim 3 of this study, older adults with Alzheimer's Disease (AD) complete 5 split-belt treadmill walking exercise sessions over a 2-week period.
Group III: Older Adults with MCI or ADExperimental Treatment1 Intervention
Older adults with MCI or AD will complete split-belt treadmill walking sessions for Aims 1 and 2 of this study.
Group IV: Healthy Older Adults (HOA)Experimental Treatment1 Intervention
Health older adults serve as a comparison group for Aims 1 and 2 of this study.

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,679 Previous Clinical Trials
2,583,606 Total Patients Enrolled
National Institute on Aging (NIA)NIH
1,733 Previous Clinical Trials
28,054,943 Total Patients Enrolled
Trisha Kesar, PT, PhDPrincipal InvestigatorEmory University
5 Previous Clinical Trials
193 Total Patients Enrolled
~40 spots leftby Jun 2025
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