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Forced Aerobic Exercise for Multiple Sclerosis
N/A
Waitlist Available
Led By Susan M Linder, DPT
Research Sponsored by The Cleveland Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 1 (exercise session 1), week 12 (exercise session 24)
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing two types of aerobic exercise for people with multiple sclerosis (MS) who have trouble walking. One type uses a motor to help them pedal faster, while the other lets them pedal at their own pace. The goal is to see if these exercises can help repair nerve cells and improve their ability to walk and move around.
Eligible Conditions
- Multiple Sclerosis
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ week 1 (exercise session 1), week 12 (exercise session 24)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 1 (exercise session 1), week 12 (exercise session 24)
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Biomechanical Gait Assessment
Exercise variables
Instrumented Timed Up and Go (TUG)
+3 moreSecondary study objectives
Modified Fatigue Impact Scale
To investigate the role of Klotho in promoting neuroprotection.
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Forced Aerobic Exercise (FE)Experimental Treatment1 Intervention
The FE group (N=10) will complete 45 minutes of FE on the custom-engineered cycle designed to augment pedaling rate to greater than 70 revolutions per minute (RPM's). The VE group (N=10) will exercise on an identical semi-recumbent cycle ergometer at their self-selected cadence without assistance.
Group II: Voluntary Aerobic Exercise (VE)Active Control1 Intervention
The VE group (N=10) will exercise on an identical semi-recumbent cycle ergometer for 45 minutes at their self-selected cadence without assistance.
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Who is running the clinical trial?
The Cleveland ClinicLead Sponsor
1,049 Previous Clinical Trials
1,370,735 Total Patients Enrolled
19 Trials studying Multiple Sclerosis
4,136 Patients Enrolled for Multiple Sclerosis
Susan M Linder, DPTPrincipal InvestigatorThe Cleveland Clinic
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You have severe muscle tightness or stiffness.You have a serious heart rhythm problem.You were in the hospital for a heart attack, heart failure, or heart surgery within the past 3 months.You have a serious narrowing of the aortic valve in your heart.You have had a blood clot in your lung.You are considered to have a low risk of having a heart problem during physical activity according to the American College of Sports Medicine.You have trouble swallowing and can't drink enough fluids.You are between 18 and 75 years old.You have another reason that makes it unsafe for you to exercise.You have a heart condition called hypertrophic cardiomyopathy.You have been diagnosed with RRMS and your disability scale score is between 1.5 and 6.5.
Research Study Groups:
This trial has the following groups:- Group 1: Forced Aerobic Exercise (FE)
- Group 2: Voluntary Aerobic Exercise (VE)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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