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Immobilization Effects on Muscle Atrophy

N/A
Recruiting
Led By Emily E Howard, PhD
Research Sponsored by United States Army Research Institute of Environmental Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 minutes
Awards & highlights
No Placebo-Only Group

Summary

This trial will study how muscles respond to being immobilized and not being used. Twelve adults will have one leg immobilized with a knee brace for five days while the other leg will be used as a

Who is the study for?
This trial is for healthy adults aged 18-39, with a BMI of 18.5-30, who exercise regularly and have no chronic illnesses or musculoskeletal injuries. Participants must avoid alcohol, nicotine products, caffeine, and dietary supplements during the study. Women should have normal menstrual cycles or be on hormonal contraception.
What is being tested?
The study tests how muscle responds to protein intake when one leg is immobilized versus the active other leg in adults. It involves wearing a knee brace for five days and consuming whey protein to examine molecular changes in muscle tissue through blood samples and biopsies.
What are the potential side effects?
There are no specific side effects mentioned for this trial as it primarily involves immobilization of a limb and consumption of whey protein; however, potential discomfort from wearing a brace and undergoing muscle biopsies may occur.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Integrated ribonucleic acid (RNA) synthesis
Intramuscular protein signaling response to protein ingestion

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Non-immobilized legExperimental Treatment1 Intervention
One leg of a young, healthy adult will remain active and not immobilized for 5 days.
Group II: Immobilized LegExperimental Treatment1 Intervention
One leg of a young, healthy adult will be randomly assigned to undergo 5 days of immobilization using a rigid knee brace.

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Who is running the clinical trial?

United States Army Research Institute of Environmental MedicineLead Sponsor
63 Previous Clinical Trials
3,598 Total Patients Enrolled
Emily E Howard, PhDPrincipal InvestigatorUS Army Research Institute of Environmental Medicine
1 Previous Clinical Trials
68 Total Patients Enrolled
~4 spots leftby May 2025
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