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Stem Cell Therapy
Stem Cell Therapy for Neurological Disorders (NEST Trial)
N/A
Recruiting
Led By Jeffrey Weiss, MD
Research Sponsored by MD Stem Cells
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Have documented functional damage to the central or peripheral nervous system unlikely to improve with present standard of care.
Be over the age of 18 and capable of providing informed consent.
Must not have
Patients must be capable of providing informed consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0,1,3,6 and 12 months
Awards & highlights
Summary
This trial is testing whether injecting stem cells into the nose can help improve neurologic function in patients with certain conditions.
Who is the study for?
Adults over 18 with stable neurologic conditions like ALS, MS, stroke, or brain injuries not expected to improve with current treatments. They must be at least 6 months post-diagnosis and cleared by a doctor as safe for the procedure. Pregnant women or those who may become pregnant within 3 months post-treatment are excluded.
What is being tested?
The trial is testing whether injecting patients' own bone marrow stem cells into their bloodstream and nasal passages can improve neurological function in various chronic diseases.
What are the potential side effects?
Potential side effects aren't specified but could include typical risks associated with medical procedures such as infection, bleeding, or an adverse reaction to the stem cell transfer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have lasting nerve damage that current treatments can't fix.
Select...
I am over 18 and can give my consent.
Select...
I have lasting nerve damage that current treatments can't fix.
Select...
I am over 18 and can give my consent.
Select...
I have lasting nerve damage that current treatments can't improve.
Select...
I am over 18 and can give my consent.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I am able to understand and agree to the study's procedures and risks.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 0,1,3,6 and 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0,1,3,6 and 12 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in Neurologic Function
Secondary study objectives
Neurologic Functioning
Trial Design
1Treatment groups
Experimental Treatment
Group I: Arm 1- Intravenous and Intranasal BMSCExperimental Treatment1 Intervention
Intervention- Autologous bone marrow aspiration and separation of Bone Marrow Derived Stem Cell (BMSC) fraction then provided intravenously and intranasally (lower 1/3 of nasal passages).
Find a Location
Who is running the clinical trial?
MD Stem CellsLead Sponsor
4 Previous Clinical Trials
940 Total Patients Enrolled
Steven Levy, MDStudy ChairMD Stem Cells
4 Previous Clinical Trials
940 Total Patients Enrolled
Jeffrey Weiss, MDPrincipal InvestigatorCoral Springs
4 Previous Clinical Trials
940 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My current treatment for my condition is stable and not expected to reverse my neurological symptoms.I am willing and able to attend follow-up neurological exams as required.My current treatment for my condition is stable and not expected to reverse any nerve damage.My disease started at least 6 months ago.I am able to understand and agree to the study's procedures and risks.My condition started at least 6 months ago.Dr. Weiss and the neurologists believe BMSC treatment could help me with minimal risk.I have lasting nerve damage that current treatments can't improve.I am over 18 and can give my consent.I have lasting nerve damage that current treatments can't fix.My current treatment for my condition is stable and not expected to reverse my neurological symptoms.Dr. Weiss and the neurologists believe I could improve with BMSC treatment without significant risk.My doctor believes I can safely undergo the procedure.I have lasting nerve damage that current treatments can't fix.Dr. Weiss and the neurologists believe I can improve with BMSC treatment without significant risk.I am over 18 and can give my consent.My doctor agrees I can safely undergo a medical procedure.I can participate fully in a neurological exam.I am over 18 and can give my consent.My condition started at least 6 months ago.
Research Study Groups:
This trial has the following groups:- Group 1: Arm 1- Intravenous and Intranasal BMSC
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Neurological Disorders Patient Testimony for trial: Trial Name: NCT02795052 — N/A
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