← Back to Search

Exercise for Obesity

N/A
Recruiting
Led By Roeland JW Middelbeek, MD
Research Sponsored by Joslin Diabetes Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
No history of diabetes (type 1 and type 2)
Age 20-60 years
Must not have
Heart or lung disease
Use of weight loss medications (i.e. GLP-1 agonists)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline; 2 hours
Awards & highlights
No Placebo-Only Group

Summary

This trial looks at how genes and small molecules in blood and fat tissue change after a workout. The findings could help explain the benefits of exercise.

Who is the study for?
This trial is for adults aged 20-60 with obesity (BMI between 30.0 and 40.0) who are generally healthy, have an HbA1c level ≤5.7%, and do not exercise frequently or have diabetes. Participants must be willing to follow the study's protocol and not take certain medications that could affect the results.
What is being tested?
The study aims to observe how a single session of exercise can change gene expression and molecule levels in blood and fat tissue, helping us understand how physical activity benefits those with obesity or metabolic syndrome.
What are the potential side effects?
Since this trial involves a bout of exercise, potential side effects may include typical post-exercise symptoms such as muscle soreness, fatigue, shortness of breath during exertion, dizziness or lightheadedness.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have never been diagnosed with diabetes.
Select...
I am between 20 and 60 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a heart or lung condition.
Select...
I am currently taking medication to help me lose weight.
Select...
I am not taking medications that affect liver sugar production.
Select...
I have been hospitalized due to COVID-19.
Select...
I am taking medication for diabetes.
Select...
My blood pressure is not higher than 160/90 mmHg.
Select...
I am currently taking beta-blockers.
Select...
I am currently taking blood thinners or aspirin.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline; 2 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline; 2 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Metabolome in fat
Transcriptome in white adipose tissue
Secondary study objectives
Transcriptomic changes in peripheral blood mononuclear cell in people with obesity

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Acute Bout of ExerciseExperimental Treatment1 Intervention
Exercising for 60 minutes at 55-60% of VO₂ peak
Group II: No ExerciseActive Control1 Intervention
No Exercise Session

Find a Location

Who is running the clinical trial?

Massachusetts Institute of TechnologyOTHER
98 Previous Clinical Trials
12,819,971 Total Patients Enrolled
3 Trials studying Obesity
3,783 Patients Enrolled for Obesity
Joslin Diabetes CenterLead Sponsor
97 Previous Clinical Trials
26,548 Total Patients Enrolled
14 Trials studying Obesity
698 Patients Enrolled for Obesity
Roeland JW Middelbeek, MDPrincipal InvestigatorJoslin Diabetes Center
~4 spots leftby Nov 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top