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100% body weight walking for Osteoarthritis (LBPPKNEEOA Trial)

N/A
Waitlist Available
Led By Prakash Jayabalan, MD, PhD
Research Sponsored by Shirley Ryan AbilityLab
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, and 45 minutes of walking
Awards & highlights

Summary

Our goal is to compare the serum biomarker changes of joint disease that occur in response to partially off-loaded (50%) walking exercise to regular (100%) walking exercise while on a Lower Body Positive Pressure (LBPP) treadmill. Secondly we are determining the relationship between changes in the concentration of these serum biomarkers and participant reported knee pain while walking on a LBPP treadmill.

Eligible Conditions
  • Osteoarthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, and 45 minutes of walking
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, and 45 minutes of walking for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Cartilage oligomeric matrix protein serum concentration
Change in Knee Joint Pain
Secondary study objectives
Change in Inflammatory cytokine (IL-6, IL-1B and TNF-A) concentration

Trial Design

2Treatment groups
Experimental Treatment
Group I: 50% body weight walkingExperimental Treatment1 Intervention
Individuals with knee osteoarthritis will walk 45 minutes on a treadmill at 50% full body weight loading
Group II: 100% body weight walkingExperimental Treatment1 Intervention
Individuals with knee osteoarthritis will walk 45 minutes on a treadmill at 100% full body weight loading

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Who is running the clinical trial?

Shirley Ryan AbilityLabLead Sponsor
204 Previous Clinical Trials
17,809 Total Patients Enrolled
3 Trials studying Osteoarthritis
133 Patients Enrolled for Osteoarthritis
Prakash Jayabalan, MD, PhD5.02 ReviewsPrincipal Investigator - Shirley Ryan AbilityLab
Shirley Ryan AbilityLab
3 Previous Clinical Trials
133 Total Patients Enrolled
3 Trials studying Osteoarthritis
133 Patients Enrolled for Osteoarthritis
5Patient Review
This doctor is incredible! They were so knowledgeable and had great bedside manner. They actually spoke to me on the phone, which I really appreciated. I would highly recommend them to anyone!
~5 spots leftby Sep 2025
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