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Behavioural Intervention

Low-Carb vs. Low-Fat Diets for Obesity

N/A
Recruiting
Led By Kevin Hall, Ph.D.
Research Sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Summary

"This trial aims to study the effects of the order in which people receive a low-fat or low-carbohydrate diet over 8 weeks. Participants will live at home but have 3 visits to the

Who is the study for?
This trial is for adults aged 19 to 50 with a BMI of 25 or higher. Participants will follow and switch between low-fat and low-carb diets over an 8-week period, all while living at home. They must be willing to visit the NIH three times, track their weight daily, monitor physical activity and glucose levels, and attend virtual meetings.
What is being tested?
The study tests whether starting with a low-carbohydrate diet leads to greater body fat loss compared to starting with a low-fat diet when each is followed for four weeks at home. Meals are provided, and participants' metabolism, bone density, muscle mass, body fat, and various health markers are monitored.
What are the potential side effects?
Potential side effects may include changes in energy levels due to dietary adjustments. Low-carb diets might cause 'keto flu,' including headache, fatigue or irritability initially. Low-fat diets could lead to hunger or dissatisfaction if not used to such eating patterns.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in total fat mass
Secondary study objectives
Rate of body weight change during low-carbohydrate diet
Rate of body weight change during low-fat diet
Rate of body weight change from baseline to week 8

Trial Design

2Treatment groups
Experimental Treatment
Group I: low-fat diet then low-carbohydrate dietExperimental Treatment2 Interventions
A low-fat followed by low-carbohydrate diet, each lasting for 4 weeks in adults with overweight or obesity
Group II: low-carbohydrate diet then low-fat dietExperimental Treatment2 Interventions
A low-carbohydrate followed by low-fat diet, each lasting for 4 weeks in adults with overweight or obesity

Find a Location

Who is running the clinical trial?

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Lead Sponsor
2,410 Previous Clinical Trials
4,324,791 Total Patients Enrolled
459 Trials studying Obesity
589,450 Patients Enrolled for Obesity
Kevin Hall, Ph.D.Principal InvestigatorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
10 Previous Clinical Trials
470 Total Patients Enrolled
6 Trials studying Obesity
414 Patients Enrolled for Obesity
~67 spots leftby Jul 2026
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