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Aphasia Rehabilitation for Primary Progressive Aphasia

N/A
Waitlist Available
Led By Aaron Meyer, PhD
Research Sponsored by Georgetown University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of Primary Progressive Aphasia (PPA; including Frontotemporal Dementia, Semantic Dementia, or a similar condition) or Diagnosis of Alzheimer's Disease
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 21 months
Awards & highlights

Summary

This trial is testing a new approach to treating word-finding problems in patients with Primary Progressive Aphasia or Alzheimer's Disease, by trying to strengthen the neural connections that remain functional.

Who is the study for?
This trial is for individuals with Primary Progressive Aphasia or Alzheimer's Disease who have at least a decade of education, can follow spoken instructions, and are fluent in English. They should be medically stable and willing to participate for two years. Those with additional neurological issues, substance abuse, or psychiatric problems cannot join.
What is being tested?
The study tests methods to improve word-finding abilities in patients by strengthening neural connections. It includes exercises like picture naming combined with writing the name, learning semantic features (meaning), and lexical features (letters and sounds) of words.
What are the potential side effects?
Since this trial involves cognitive training exercises rather than medication or invasive procedures, traditional side effects are not expected; however, participants may experience fatigue or frustration during the tasks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with Primary Progressive Aphasia or Alzheimer's Disease.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 21 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 21 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in picture naming accuracy for words within each treatment condition during treatment
Secondary study objectives
Change in picture naming accuracy for words within each treatment condition between baseline and first follow-up assessment
Change in picture naming accuracy for words within each treatment condition between baseline and second follow-up assessment

Trial Design

2Treatment groups
Experimental Treatment
Group I: Semantic, Lexical, UntrainedExperimental Treatment3 Interventions
Group II: Phonological, Orthographic, UntrainedExperimental Treatment3 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Phonological
2019
N/A
~150
Semantic
2017
N/A
~290

Find a Location

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,733 Previous Clinical Trials
28,054,919 Total Patients Enrolled
Johns Hopkins UniversityOTHER
2,307 Previous Clinical Trials
14,861,825 Total Patients Enrolled
Georgetown UniversityLead Sponsor
346 Previous Clinical Trials
137,126 Total Patients Enrolled
1 Trials studying Anomia
78 Patients Enrolled for Anomia
~6 spots leftby Sep 2025
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