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Probiotic

Probiotic for High Altitude Acclimatization

N/A
Waitlist Available
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Provision of signed and dated informed consent form. Participants must have the cognitive ability to consent to participate in this study.
Persons aged ≥ 18 years old or ≤ 65 years old.
Must not have
Participants with a BMI higher than 35.
History of cardiovascular or pulmonary disease, including HAPE and HACE.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at sea level (one day) and all four days of the study at high altitude
Awards & highlights

Summary

"This trial aims to see if a probiotic called SLAB51 helps people adjust better to high altitudes. Participants will take SLAB51 or a placebo three times daily during two separate acclimat

Who is the study for?
This trial is for people who are healthy but want to see if a probiotic called SLAB51 helps with getting used to high altitudes. Participants will take the probiotic or a placebo before and during stays at a high-altitude research station.
What is being tested?
The study tests whether SLAB51 improves oxygen levels in the blood at high altitude compared to a placebo. It involves taking the substance three times daily over two separate three-night periods at an elevation of 3,801 meters, with various health measurements taken.
What are the potential side effects?
While specific side effects aren't listed, common side effects of probiotics can include digestive discomfort such as gas or bloating, especially when first starting them.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I understand and agree to participate in this study.
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I am between 18 and 65 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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My BMI is over 35.
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I have a history of heart or lung disease.
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I currently have an infection.
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I have a weakened immune system.
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I am not pregnant and my menstrual cycle and birth control use are documented.
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I have had acute pancreatitis or severe allergies to gluten or lactose.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at sea level (one night) and all three nights of the study at high altitude
This trial's timeline: 3 weeks for screening, Varies for treatment, and at sea level (one night) and all three nights of the study at high altitude for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Oxygen saturation
Secondary study objectives
Acute Mountain Sickness Score
Blood pressure
Cancellation Pictures cognitive test
+13 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Probiotic groupExperimental Treatment1 Intervention
SLAB51 will be administered orally each day during the four days at high altitude. Each dose of SLAB51 consists of one six-gram sachet dissolved in 100 mL of water, containing approximately 800 billion bacteria. Participants will receive, in one of their trips, one dose of SLAB51 after arrival to high altitude, then three times a day approximately every 5 hours upon waking during Days 2 and 3, and a final dose the morning of Day 4 of acclimatization.
Group II: Placebo groupPlacebo Group1 Intervention
Placebo will be administered in the other trip, following the same schedule as SLAB51 as described above.

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Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,157 Previous Clinical Trials
1,571,402 Total Patients Enrolled
~7 spots leftby Oct 2025
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