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IMT for Post-CABG Recovery

N/A
Waitlist Available
Led By Cemal Ozemek, Assoc. Prof.
Research Sponsored by University of Illinois at Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Had coronary artery bypass graft (CABG) surgery
Be able to walk independently
Must not have
Having had any other previous cardiothoracic operation except CABG (e.g. Pneumonectomy, lobectomy, etc.)
Having a history of unstable-angina
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 4 weeks

Summary

This trial will investigate if high-intensity inspiratory muscle training after CABG surgery can improve endothelial function and reduce arterial stiffness.

Who is the study for?
This trial is for adults over 18 who can walk on their own and have had coronary artery bypass graft (CABG) surgery. They must understand English well enough to consent and follow the study's instructions. People with recent pneumonia, other cardiothoracic surgeries, current smokers, unstable angina, certain chronic diseases, cognitive impairments or those on antipsychotic meds cannot join.
What is being tested?
The trial tests if high-intensity inspiratory muscle training (IMT) improves heart and artery function after CABG surgery compared to a sham-IMT. Participants are randomly assigned to either real IMT at 60% of their max breathing power or a fake version for four weeks while cardiovascular functions are monitored.
What are the potential side effects?
Potential side effects may include discomfort from intense breathing exercises and possible strain on respiratory muscles due to high-intensity training. However, specific side effects will be closely monitored throughout the study.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have had heart bypass surgery.
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I can walk on my own without help.
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I am older than 18 years.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had heart or lung surgery, but not CABG.
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I have a history of unstable chest pain.
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I am taking medication for schizophrenia or schizoaffective disorder.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
arterial stiffness
endothelial function
inspiratory muscle function
Secondary study objectives
dyspnea
functional exercise capacity

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Study GroupExperimental Treatment1 Intervention
Patients who will perform inspiratory muscle training (IMT) with %60 of MIP intensity
Group II: Sham GroupPlacebo Group1 Intervention
Patients who will perform Sham-IMT
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
IMT
2015
N/A
~60

Find a Location

Who is running the clinical trial?

University of Illinois at ChicagoLead Sponsor
638 Previous Clinical Trials
1,569,085 Total Patients Enrolled
TUBİTAKUNKNOWN
6 Previous Clinical Trials
616 Total Patients Enrolled
The Scientific and Technological Research Council of TurkeyOTHER
148 Previous Clinical Trials
20,200 Total Patients Enrolled
~24 spots leftby Nov 2025
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