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Alpha-2 Adrenergic Agonist

Dexmedetomidine for Postoperative Lung Complications

N/A
Recruiting
Led By Matthew B Allen, MD
Research Sponsored by Brigham and Women's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult patients (Age >18 years until 80 years) undergoing lobectomy and/or segmentectomy.
Be older than 18 years old
Must not have
Urgent or emergency thoracic surgery
Prior lung resection surgery
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights

Summary

"This trial will test whether giving a drug called dexmedetomidine during thoracic surgery is helpful. Dexmedetomidine is often used during these surgeries, but there is no agreement on the

Who is the study for?
This trial is for patients undergoing thoracic surgery who may benefit from a drug called Dexmedetomidine to improve lung function post-surgery. The study excludes those with specific health conditions or factors that could interfere with the trial's outcomes, but details on these are not provided.
What is being tested?
The study tests if Dexmedetomidine, given as an initial bolus and then infused during surgery, can help maintain better lung aeration after thoracic surgery compared to a placebo (saline solution). Participants will be randomly assigned to either the drug or placebo group in equal numbers.
What are the potential side effects?
While specific side effects of Dexmedetomidine in this context aren't listed, it generally can cause low blood pressure, slow heart rate, dry mouth, and drowsiness. Side effects vary by individual.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 80 years old and scheduled for a lung surgery.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I need urgent or emergency surgery in my chest area.
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I have had surgery to remove part of my lung.
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I will have an epidural for pain relief during or after surgery.
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I do not have severe liver or kidney disease.
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I have a slow heartbeat or a specific heart rhythm problem.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Lung aeration
Secondary study objectives
Acute Respiratory Distress Syndrome (ARDS)
Diaphragmatic dysfunction: defined as a diaphragmatic excursion < 1cm
Intraoperative hypoxemia (SpO2 < 90%)
+4 more

Side effects data

From 2015 Phase 4 trial • 60 Patients • NCT03078946
3%
Delirium
100%
80%
60%
40%
20%
0%
Study treatment Arm
Dexmedetomidine Group (N=30)
Morphine With Midazolam (N=30)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: DexmedetomidineExperimental Treatment1 Intervention
Dexmedetomidine infusion arm
Group II: PlaceboPlacebo Group1 Intervention
Normal saline infusion arm
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Dexmedetomidine Hydrochloride
2013
Completed Phase 4
~940

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor
1,653 Previous Clinical Trials
11,490,935 Total Patients Enrolled
1 Trials studying Postoperative Complications
Matthew B Allen, MDPrincipal InvestigatorBrigham and Women's Hospital
~67 spots leftby Mar 2026
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