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Behavioral Activation Therapy for Depression After Respiratory Failure (BEHAB Trial)

N/A

Recruiting

Led By Ann M Parker, MD

Research Sponsored by Johns Hopkins University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

At least mild depressive symptoms (score ≥2 on PHQ-2 scale)

Acute respiratory failure managed in the ICU > 24hrs with specific ventilation or oxygenation criteria

Must not have

Not discharged home from the hospital

ICU Length Of Stay (LOS) > 30 days

Timeline

Screening 3 weeks

Treatment Varies

Follow Up end of intervention (12 weeks)

Awards & highlights

Summary

This trial looks at a new therapy to help people who have survived respiratory failure and are struggling with depression and physical problems.

Who is the study for?

This trial is for adults over 18 who were living at home before ICU admission, experienced acute respiratory failure requiring intensive care for more than 24 hours, and have mild depressive symptoms. Excluded are those with long ICU stays, substance abuse or psychosis, severe prior disability, non-English speakers, homelessness or living far from the study site.

What is being tested?

The study tests a combined therapy approach delivered through phone calls and home visits to treat depression and improve physical function in patients who've had serious respiratory issues requiring life support.

What are the potential side effects?

Since this is a behavioral intervention focusing on mental health and physical rehabilitation rather than medication, side effects may include emotional discomfort during therapy sessions but are generally expected to be minimal.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I experience mild depression symptoms.

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I was in the ICU for over 24 hours for severe breathing problems needing special breathing support.

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I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have not been sent home from the hospital.

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I have been in the ICU for more than 30 days.

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I was bedbound before being admitted this time.

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I am unable or unwilling to give my consent for participation.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ end of intervention (12 weeks)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~end of intervention (12 weeks)

This trial's timeline: 3 weeks for screening, Varies for treatment, and end of intervention (12 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Feasibility measure

Feasibility measure per participant

Feasibility measure/Assess loss to follow-up

+1 more

Secondary study objectives

Activity Measure for Post-Acute Care Computer Adaptive Test (AMPAC-CAT)

Behavioral Activation for Depression SCALE (BAS)

Brief Coping with Problems Experienced (Brief COPE)

+10 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Behavioral Activation - RehabilitationExperimental Treatment1 Intervention

Behavioral Activation - Rehabilitation

Group II: Usual Care ControlActive Control1 Intervention

Usual Care Control

0 / 7Eligibility criteria met

Find a Location

Who is running the clinical trial?

Johns Hopkins UniversityLead Sponsor

2,307 Previous Clinical Trials

14,861,855 Total Patients Enrolled

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,889 Previous Clinical Trials

47,834,153 Total Patients Enrolled

1 Trials studying Rehabilitation

30 Patients Enrolled for Rehabilitation

Ann M Parker, MDPrincipal InvestigatorJohns Hopkins University

Media Library

Behavioral Activation - Rehabilitation Clinical Trial Eligibility Overview. Trial Name: NCT03431493 — N/A

Rehabilitation Research Study Groups: Behavioral Activation - Rehabilitation, Usual Care Control

Rehabilitation Clinical Trial 2023: Behavioral Activation - Rehabilitation Highlights & Side Effects. Trial Name: NCT03431493 — N/A

Behavioral Activation - Rehabilitation 2023 Treatment Timeline for Medical Study. Trial Name: NCT03431493 — N/A

~5 spots leftby Jun 2025

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