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Auditory Stimulation for Schizophrenia

N/A
Recruiting
Led By Dara Manoach, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18-50 years of age
Male and female schizophrenia outpatients
Timeline
Screening 3 weeks
Treatment Varies
Follow Up placebo and auditory stimulation naps will be approximately one week apart
Awards & highlights

Summary

This trial will test whether playing quiet sounds during sleep can normalize brain activity and improve memory in patients with schizophrenia.

Who is the study for?
This trial is for English-speaking men and women aged 18-50 who have been diagnosed with schizophrenia. Participants must be outpatients, meaning they aren't currently in the hospital, and able to give informed consent to participate.
What is being tested?
The study is examining if playing quiet sounds during sleep (auditory stimulation) can help normalize brain activity and improve memory in people with schizophrenia compared to a placebo (no sound).
What are the potential side effects?
Since this trial involves auditory stimulation which is non-invasive, side effects are expected to be minimal but may include disturbances in sleep patterns or discomfort due to wearing headphones during sleep.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 50 years old.
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I am an outpatient being treated for schizophrenia.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~placebo and auditory stimulation naps will be approximately one week apart
This trial's timeline: 3 weeks for screening, Varies for treatment, and placebo and auditory stimulation naps will be approximately one week apart for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Differences in slow-oscillation spindle coupling
Secondary study objectives
Differences in sleep spindles
Differences in sleep-dependent consolidation of motor procedural memory
Differences in slow oscillations

Trial Design

2Treatment groups
Experimental Treatment
Group I: SchizophreniaExperimental Treatment2 Interventions
Adult outpatients with a diagnosis of schizophrenia.
Group II: Healthy ControlsExperimental Treatment2 Interventions
Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use.

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor
2,993 Previous Clinical Trials
13,230,651 Total Patients Enrolled
46 Trials studying Schizophrenia
7,236 Patients Enrolled for Schizophrenia
Dara Manoach, PhDPrincipal InvestigatorMassachusetts General Hospital
2 Previous Clinical Trials
80 Total Patients Enrolled

Media Library

Auditory Stimulation Clinical Trial Eligibility Overview. Trial Name: NCT04783571 — N/A
Schizophrenia Research Study Groups: Schizophrenia, Healthy Controls
Schizophrenia Clinical Trial 2023: Auditory Stimulation Highlights & Side Effects. Trial Name: NCT04783571 — N/A
Auditory Stimulation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04783571 — N/A
~3 spots leftby Dec 2024
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