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Behavioural Intervention

Brain Stimulation for PTSD

N/A
Recruiting
Led By Lily A Brown, PhD
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up days 4, 5, 34 and 35

Summary

"This trial will be the first to study the effects of continuous theta burst stimulation on a specific brain region in patients with posttraumatic stress disorder. The researchers aim to show that this stimulation can reduce arousal

Who is the study for?
This trial is for right-handed adults aged 18-60 with PTSD, as diagnosed by the DSM-5 criteria. Participants must not have any metal implants in their body.
What is being tested?
The study tests if a brain stimulation technique called Continuous Theta Burst Stimulation (cTBS) to the Intraparietal Sulcus can reduce arousal symptoms in PTSD patients compared to sham (fake) treatment.
What are the potential side effects?
Possible side effects of cTBS may include discomfort at the stimulation site, headache, lightheadedness, or temporary changes in thinking or mood.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~days 4, 5, 34 and 35
This trial's timeline: 3 weeks for screening, Varies for treatment, and days 4, 5, 34 and 35 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Electromyography startle response
Secondary study objectives
Negative outcome expectancy
Subjective Units of Distress (SUDS)
fMRI

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Continuous theta burst stimulation to the intraparietal sulcusExperimental Treatment1 Intervention
Continuous theta burst stimulation will be delivered to the individually targeted intraparietal sulcus site at 100% RMT.
Group II: Sham continuous theta burst stimulationPlacebo Group1 Intervention
We will use the coil's electric stimulation functionality that allows for the delivery of a brief electric pulse to the scalp simultaneous to the pulse to mimic actual stimulation.

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Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,075 Previous Clinical Trials
42,719,726 Total Patients Enrolled
Lily A Brown, PhDPrincipal InvestigatorUniversity of Pennsylvania
~80 spots leftby Jul 2028
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