← Back to Search

Behavioural Intervention

Standard transport protocol for Stroke (OPUS-i Trial)

N/A
Waitlist Available
Led By Derek Isenberg, MD
Research Sponsored by Temple University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Clinical impression of stroke/TIA by EMS clinicians
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up modified rankin scale of 0-2 at 90 days in patients with last known well to hospital arrival of <4 hour
Awards & highlights

Summary

This interventional trial will compare a novel prehospital stroke transport algorithm (OPUS-i) to a traditional prehospital stroke transport algorithm to improve outcomes in rural stroke patients by determining the effect of implementing a data-driven prehospital stroke algorithm on time to and endovascular therapy. The study consists of a multicenter cohort and will last 24 months but individual subject study duration is 90 days.

Who is the study for?
This trial is for stroke patients in rural areas. It's testing if a new prehospital transport method (OPUS-i algorithm) can get them to treatment faster than the old way. Participants must be within the study's regional boundaries and able to follow up.
What is being tested?
The OPUS-i trial is comparing a new data-driven algorithm for transporting stroke patients against traditional methods, focusing on how quickly they receive endovascular therapy over a 90-day period per patient.
What are the potential side effects?
Since this trial involves an algorithm for transportation rather than medication, there are no direct side effects from drugs or treatments being tested.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~modified rankin scale of 0-2 at 90 days in patients with last known well to hospital arrival of <4 hour
This trial's timeline: 3 weeks for screening, Varies for treatment, and modified rankin scale of 0-2 at 90 days in patients with last known well to hospital arrival of <4 hour for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Time from stroke onset to endovascular therapy
Secondary study objectives
Rate of bypass of non-ESCs for rural and urban patients.
Time from stroke onset IVT
To compare the above processes and outcomes in rural versus urban patients
+16 more

Trial Design

2Treatment groups
Active Control
Group I: Standard transport protocolActive Control1 Intervention
Standard EMS stroke transport protocol
Group II: OPUS-i ProtocolActive Control1 Intervention
Experimental OPUS-i protocol

Find a Location

Who is running the clinical trial?

Temple UniversityLead Sponsor
309 Previous Clinical Trials
87,559 Total Patients Enrolled
3 Trials studying Stroke
292 Patients Enrolled for Stroke
Derek Isenberg, MDPrincipal InvestigatorLewis Katz School of Medicine at Temple University
1 Previous Clinical Trials
10 Total Patients Enrolled
~240 spots leftby Jun 2026
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top