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Behavioural Intervention

Muscle Coordination Training for Stroke (NICE Trial)

N/A
Recruiting
Led By Jinsook Roh, PhD
Research Sponsored by University of Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Must not have
Aged matched healthy group: Orthopedic disorder involving upper limbs, history of any neurologic disease, history of epilepsy of the potential participants and/or their family members, inability to consent, pregnancy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up before any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively
Awards & highlights

Summary

"This trial aims to determine if certain abnormal muscle coordination patterns can predict motor impairment after a stroke. Additionally, the study will investigate if a specific exercise, guided by EMG signals, can change muscle coordination

Who is the study for?
This trial is for adults aged 40-75 who have had a stroke and are stable, without severe muscle stiffness or recent botulinum toxin treatments. Healthy individuals with no neurological issues can also join. People with upper limb disorders, cognitive impairments, other neurological diseases, or pregnant women cannot participate.
What is being tested?
The study tests two types of rehabilitative training to improve arm control after a stroke: one focuses on neuromuscular coordination and the other on strength building. It aims to see if these methods can change how muscles work together post-stroke.
What are the potential side effects?
Since this trial involves non-invasive rehabilitative training exercises rather than medication, side effects may include muscle soreness or fatigue from the physical activity involved in the therapy sessions.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am healthy, not pregnant, can consent, and have no history of neurological diseases or epilepsy in my family.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~before any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively
This trial's timeline: 3 weeks for screening, Varies for treatment, and before any training, after the 6 weeks of training, respectively, and 1 and 3 months after the last training session, respectively for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in Action Research Arm Test (ARAT) score
Change in Fugl-Meyer Assessment (FMA) score
Change in intermuscular coordination patterns
Secondary study objectives
Brain imaging data recording

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Neuromuscular coordination-guided rehabilitative trainingExperimental Treatment1 Intervention
Post-stroke participants will perform a center-out task by generating isometric contractions of multiple muscles to move the cursor on a screen while electromyographic (EMG) responses are recorded. Activation of each muscle (or muscle group) will be mapped to 1 of 4 directions within the multi-dimensional cursor space. We will derive the cursor position in real time using EMGs recorded from multiple arm muscles.
Group II: Force strengthening-guided rehabilitative trainingActive Control1 Intervention
Post-stroke participants will perform a center-out task by generating isometric force to move the cursor on a screen. Participants will generate isometric force, which will move their cursor on the monitor. They will be trained to match one of the four force targets on display. We will derive the cursor position in real time using three forces (Fx, Fy, and Fz) measured at the load cell.

Find a Location

Who is running the clinical trial?

Korea Advanced Institute of Science and TechnologyOTHER
4 Previous Clinical Trials
1,315 Total Patients Enrolled
University of HoustonLead Sponsor
149 Previous Clinical Trials
47,798 Total Patients Enrolled
6 Trials studying Stroke
143 Patients Enrolled for Stroke
UT Health HoustonUNKNOWN
~49 spots leftby Sep 2029
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