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Avocado Mango for Pre-diabetes (AVMa Trial)
N/A
Waitlist Available
Led By Britt Burton-Freeman, Ph.D
Research Sponsored by Clinical Nutrition Research Center, Illinois Institute of Technology
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline-8 weeks
Awards & highlights
Summary
This trial tests if eating one avocado and one mango daily can help people with prediabetes by improving their blood vessel health, cognitive function, and kidney function. Mangos have shown antidiabetic, anti-inflammatory, and heart-protective properties.
Who is the study for?
This trial is for men and women aged 25-70 with prediabetes, having fasting blood glucose levels between 100-125 mg/dL. Participants should be in good health without major diseases or recent surgeries that could affect the study's results. They shouldn't take medications or supplements that might interfere with outcomes, must not abuse substances, and non-smokers are preferred.
What is being tested?
The study tests how eating avocados and mangos affects vascular function over 8 weeks compared to a control diet. It measures changes in artery flexibility, blood pressure, eye vessel health using OCTA technology, cognitive performance through specific tasks, and kidney function indicators.
What are the potential side effects?
While the trial does not focus on side effects of avocado and mango consumption directly, potential side effects may include digestive discomfort or food-related allergies for those sensitive to these fruits.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline-8 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline-8 weeks
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Changes in Central Blood pressure
Changes in Kidney function markers
Changes in Pulse Wave Velocity
+9 moreSecondary study objectives
Changes in Cognitive Function
Changes in Cognitive Function-1
Changes in Cognitive Function-2
+7 moreTrial Design
2Treatment groups
Experimental Treatment
Group I: Control meal planExperimental Treatment1 Intervention
2 meals and snacks per day, without avocado and mango, covering 75% of daily calories needs
Group II: Avocado mango meal planExperimental Treatment1 Intervention
2 meals and snacks per day, including 1 avocado + 1 cup of mango, covering 75% of daily calories needs,
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for prediabetes often include dietary interventions that focus on the intake of bioactive compounds such as antioxidants, vitamins, and healthy fats. These compounds can improve insulin sensitivity, reduce oxidative stress, and enhance vascular function.
For example, antioxidants help neutralize free radicals, reducing inflammation and oxidative damage to cells, which is crucial for maintaining healthy blood sugar levels. Vitamins, particularly those with anti-inflammatory properties, support metabolic processes and improve insulin function.
Healthy fats, such as those found in avocados, can improve lipid profiles and reduce insulin resistance. These mechanisms are vital for prediabetes patients as they help prevent the progression to type 2 diabetes and reduce the risk of associated cardiovascular complications.
Natural Products Derived from the Mediterranean Diet with Antidiabetic Activity: from Insulin Mimetic Hypoglycemic to Nutriepigenetic Modulator Compounds.
Natural Products Derived from the Mediterranean Diet with Antidiabetic Activity: from Insulin Mimetic Hypoglycemic to Nutriepigenetic Modulator Compounds.
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Who is running the clinical trial?
Clinical Nutrition Research Center, Illinois Institute of TechnologyLead Sponsor
54 Previous Clinical Trials
2,920 Total Patients Enrolled
Hass Avocado BoardOTHER
12 Previous Clinical Trials
681 Total Patients Enrolled
National Mango BoardOTHER
6 Previous Clinical Trials
221 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have not donated blood in the last 3 months.I am between 25 and 70 years old.I am in good health with no major organ diseases.I am not pregnant and do not plan to become pregnant during the study.I can keep up with my normal physical activities.I am not on any medication that could affect the study's results.My fasting blood sugar is between 100 and 125 mg/dL.Your blood pressure should be between 120-160 for the top number and 80-100 for the bottom number when you visit the doctor.I have not smoked for at least 12 months.I have serious mental health or neurological conditions.I haven't had major surgery or serious injury in the last 2 months.I have had a head injury in the last 6 months.I have not had any cancer except non-melanoma skin cancer in the last 5 years.I have not abused alcohol or drugs in the last 2 years.I have taken antibiotics in the last 2 months.I work unusual hours, such as overnight.I have a history of major organ disease or surgery that might affect the study.My vision isn't fully correctable, and I have high eye pressure or severe astigmatism.I drink more than 4 cups of coffee or tea daily.My blood pressure is higher than 160/100 mmHg.My fasting blood sugar is either below 100 or above 125 mg/dL.Your Thyroid-stimulating Hormone (TSH) levels are not normal during the screening visit.I have diabetes.I am willing to stop taking certain supplements or medications that could affect the study.I follow a vegan or other strict diet.I have smoked or vaped within the last year.My weight has been stable; I haven't tried to change it or seen changes of more than 11 lbs in the last 2 months.I have been diagnosed with an eating disorder by a healthcare professional.I regularly engage in intense exercise or am an athlete.I have been on the same birth control brand and dose for less than 6 months.
Research Study Groups:
This trial has the following groups:- Group 1: Avocado mango meal plan
- Group 2: Control meal plan
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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