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Timing of Breathing Tests for Patients on Ventilators

N/A

Recruiting

Led By JIE LI, PhD

Research Sponsored by Rush University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adults aged 21 years or older

Patients who have been on mechanical ventilation for more than 48 hours

Must not have

Patients intubated for surgical or interventional procedures

Patients with a tracheostomy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from enrollment to the end of study at 28 days

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to see how the timing of breathing tests affects recovery for ICU patients on ventilators. They will compare two timing strategies: one group will have the test early morning, while the other group

Who is the study for?

This trial is for adult ICU patients who are currently on mechanical ventilation. It's designed to see if the timing of a breathing test, which checks if they can breathe without help, affects their recovery.

What is being tested?

The study is testing whether conducting Spontaneous Breathing Trials (SBTs) early in the morning or later in the morning leads to better outcomes for patients needing ventilator support in the ICU.

What are the potential side effects?

Since this trial involves only changing the timing of an already routine procedure and not testing a new medication or device, there are no additional side effects expected beyond those typically associated with SBTs.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 21 years old or older.

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I have been on a breathing machine for more than 2 days.

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I have completed at least one session of brief therapy.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I was intubated for a surgery or procedure.

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I have a tracheostomy.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from enrollment to the end of study at 28 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from enrollment to the end of study at 28 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and from enrollment to the end of study at 28 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

mechanical ventilation duration

Secondary study objectives

Duration Between SBT Success and Extubation

ICU and Hospital Lengths of Stay

ICU and Hospital Mortality

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Later morning timing of spontaneous breathing trialExperimental Treatment1 Intervention

Later Morning Group: Patients in this group will have their SBTs scheduled between 8:00 AM and 9:00 AM, closer to the time of day shift rounds.

Group II: Early morning timing of spontaneous breathing trialActive Control1 Intervention

Early Morning Group: Patients in this group will undergo their SBTs between 4:00 AM and 5:00 AM, following the traditional early morning schedule used in some ICUs.

0 / 5Eligibility criteria met