Popular Trials
Monoclonal Antibodies
Sarilumab for Juvenile Idiopathic Arthritis
This trial is testing sarilumab, a medication that reduces inflammation, in children and teenagers with a specific type of arthritis called sJIA. The medication works by blocking a protein that causes inflammation.
Behavioural Intervention
Virtual Self-Management Program for Juvenile Arthritis
This trial aims to test a virtual self-management program for adolescents with JIA across different provinces. Participants will be divided into two groups - one group will participate in the program while the other group will receive
Behavioural Intervention
PREP Intervention for Youth with Physical Disabilities
This trial studies how working with a therapist builds capacity for youth with physical disabilities to do activities of their choice in the community. They'll work with an OT for 8 weeks, then try it on their own for 8 weeks and with support for 6 weeks. They'll also rate their performance and share their experience.
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Trials for JIA Patients
Behavioural Intervention
Diet Intervention for Juvenile Arthritis
This trial aims to investigate whether a Mediterranean Diet-based diet can improve arthritis in children by studying its effects on the gut microbiome. Fifty-four participants will change their diet for 8 weeks, with the
Janus Kinase (JAK) Inhibitor
Upadacitinib + Tocilizumab for Juvenile Idiopathic Arthritis
This trial is evaluating a potential new treatment for juvenile idiopathic arthritis, a chronic disease that affects children and can continue into adulthood. Participants will receive either upadacitinib or tocilizumab and be assessed for adverse events and disease activity.
Behavioural Intervention
Online yoga training (Group A) +1 More for Juvenile Idiopathic Arthritis
The primary objectives of the proposed pilot randomized controlled trial (RCT) will be to examine: (1) the feasibility of a full RCT to evaluate the effectiveness of two popular types of physical activity (PA), a yoga training program and an aerobic dance training program, in female adolescents (13 to 18 years old) with juvenile idiopathic arthritis (JIA) compared to a wait list control group; and (2) the acceptability of these interventions. A three-arm prospective randomized open-label study with a parallel group design will be used. A total of 25 in a ratio of 2:2:1 female adolescents with JIA who have pain will be randomized to one of the three groups: 1) online yoga training program (Group A) (n=10), 2) online aerobic dance training program (Group B) (n=10) and 3) waiting list control group (Group C) (n=5). Participants in groups A and B will complete three individual 1-hour sessions per week using online exercise videos, as well as one 1-hour virtual group session per week using a video-conferencing platform (GoToMeeting) for 12 weeks. These participants will also take part in weekly e-consultations with a research coordinator and discussions on Facebook with other participants. Participants from all groups will be given access to an electronic educational pamphlet on PA for arthritis developed by The Arthritis Society to review via an online platform. Feasibility, acceptability and usability of Facebook and GoToMeeting will be assessed at the end of the program. Pain intensity (Primary outcome), participation in general physical activity, morning stiffness, functional status, fatigue, self-efficacy and patient global assessment will be assessed using self-administered electronic surveys at baseline, weekly until the end of the 12 weeks program.
Janus Kinase (JAK) Inhibitor
Upadacitinib for Juvenile Arthritis
This trial is testing a medication called upadacitinib in children with a type of arthritis that affects many joints. The study aims to see how the drug behaves in their bodies, how safe it is, and how well they can tolerate it. Upadacitinib works by reducing inflammation and pain by blocking certain enzymes in the body. It has been approved for treating rheumatoid arthritis in adults.
Phase 3 Trials
Janus Kinase (JAK) Inhibitor
Upadacitinib + Tocilizumab for Juvenile Idiopathic Arthritis
This trial is evaluating a potential new treatment for juvenile idiopathic arthritis, a chronic disease that affects children and can continue into adulthood. Participants will receive either upadacitinib or tocilizumab and be assessed for adverse events and disease activity.
Monoclonal Antibodies
Emapalumab for MAS in Still's Disease or Lupus
This trial is testing emapalumab, a medication that helps control an overactive immune system, in children and adults with certain immune conditions who haven't responded to high-dose steroids. The goal is to see if it is safe and effective in reducing excessive inflammation. Emapalumab is a monoclonal antibody that targets interferon-γ and was first approved for treating primary hemophagocytic lymphohistiocytosis (HLH) in patients with refractory, recurrent, or progressive disease.
Trials With No Placebo
Behavioural Intervention
Diet Intervention for Juvenile Arthritis
This trial aims to investigate whether a Mediterranean Diet-based diet can improve arthritis in children by studying its effects on the gut microbiome. Fifty-four participants will change their diet for 8 weeks, with the
Janus Kinase (JAK) Inhibitor
Upadacitinib + Tocilizumab for Juvenile Idiopathic Arthritis
This trial is evaluating a potential new treatment for juvenile idiopathic arthritis, a chronic disease that affects children and can continue into adulthood. Participants will receive either upadacitinib or tocilizumab and be assessed for adverse events and disease activity.
Behavioural Intervention
Online yoga training (Group A) +1 More for Juvenile Idiopathic Arthritis
The primary objectives of the proposed pilot randomized controlled trial (RCT) will be to examine: (1) the feasibility of a full RCT to evaluate the effectiveness of two popular types of physical activity (PA), a yoga training program and an aerobic dance training program, in female adolescents (13 to 18 years old) with juvenile idiopathic arthritis (JIA) compared to a wait list control group; and (2) the acceptability of these interventions. A three-arm prospective randomized open-label study with a parallel group design will be used. A total of 25 in a ratio of 2:2:1 female adolescents with JIA who have pain will be randomized to one of the three groups: 1) online yoga training program (Group A) (n=10), 2) online aerobic dance training program (Group B) (n=10) and 3) waiting list control group (Group C) (n=5). Participants in groups A and B will complete three individual 1-hour sessions per week using online exercise videos, as well as one 1-hour virtual group session per week using a video-conferencing platform (GoToMeeting) for 12 weeks. These participants will also take part in weekly e-consultations with a research coordinator and discussions on Facebook with other participants. Participants from all groups will be given access to an electronic educational pamphlet on PA for arthritis developed by The Arthritis Society to review via an online platform. Feasibility, acceptability and usability of Facebook and GoToMeeting will be assessed at the end of the program. Pain intensity (Primary outcome), participation in general physical activity, morning stiffness, functional status, fatigue, self-efficacy and patient global assessment will be assessed using self-administered electronic surveys at baseline, weekly until the end of the 12 weeks program.
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Frequently Asked Questions
Introduction to juvenile idiopathic arthritis
What are the top hospitals conducting juvenile idiopathic arthritis research?
In the realm of clinical trials for juvenile idiopathic arthritis, several hospitals have emerged as leaders in research and treatment. Cincinnati Children's Hospital Medical Center, located in the vibrant city of Cincinnati, is currently conducting three active trials dedicated to this condition. With a track record of 10 previous juvenile idiopathic arthritis trials dating back to their initial investigation in 1994, this hospital has been at the forefront of breakthroughs and advancements.
On the West Coast, Childrens Hospital Los Angeles has recently joined the ranks with two ongoing clinical trials for juvenile idiopathic arthritis. Although they may be newcomers compared to some other institutions, it's worth noting that CHLA already made significant progress by initiating their first trial on this subject as early as 2022.
Similarly contributing to cutting-edge research is the University of North carolina in Chapel Hill. They are presently engaged in two active clinical trials focused on improving treatments for children affected by juvenile idiopathic arthritis. While UNC may have entered this field more recently with their inaugural trial taking place only two years ago in2019; their commitment speaks volumes about potential discoveries yet to come.
Heading towards Salt Lake City brings us to another notable institution: The University of Utah.In addition,you can find vigorous dedication towards finding answers via two ongoing investigations but also previously completed four others since starting its journey into understanding Juvenile Idiopathic Arthritis from backin2007.
Finally,Hackensack University Medical Center situated Hackensack offers another invaluable contribution through its involvement within both current combating techniques via participation among two existingtrials alongside past accomplishments stretching over five overall experiments concerning JIA under scrutiny since setting foot onto path-of-discovery parallelly beginningfrom year2007
These hospitals serve not only as beacons of hope but also symbolize collaboration between medical professionals and families impacted by juvenile idiopathic arthritis across different regions.They showcase a combinationof expertise and determination vitalto advancing knowledgeand patient care.It isthrough these collective efforts that we march closer to finding more effective treatments, enhanced quality of life, and ultimately a cure for those living with this complex autoimmune condition.
Which are the best cities for juvenile idiopathic arthritis clinical trials?
When it comes to clinical trials for juvenile idiopathic arthritis (JIA), several cities are at the forefront of research and development. Cincinnati, Ohio leads with 8 active trials exploring treatments like Ustekinumab, Upadacitinib, Sarilumab, among others. Chicago, Illinois closely follows with 7 ongoing studies investigating Tofacitinib, Ustekinumab, Abatacept Injection, and more. Calgary in Alberta also has 7 active trials focusing on Upadacitinib, iPeer2Peer Mentorship program, Sarilumab SAR153191 (REGN88), and other interventions. These cities offer individuals with JIA access to cutting-edge clinical trials that pave the way for advancements in care and improved outcomes.
Which are the top treatments for juvenile idiopathic arthritis being explored in clinical trials?
Exciting developments are underway in the realm of juvenile idiopathic arthritis (JIA) treatment, with several promising options being explored in ongoing clinical trials. Leading the way is ustekinumab, currently involved in two active trials dedicated to JIA since its introduction in 2022. Also making significant strides is abatacept injection, showing promise with one ongoing trial and first listed as a treatment option for JIA back in 2019. Equally noteworthy is upadacitinib, which has garnered attention through one active trial and two all-time JIA trials since its debut also in 2019. Lastly, iPeer2Peer mentorship presents an innovative approach to supporting patients, boasting one active trial and establishing itself as a potential avenue for addressing JIA challenges since 2017. As researchers continue their endeavors to improve outcomes for young individuals with JIA, these treatments offer hope on the horizon.
What are the most recent clinical trials for juvenile idiopathic arthritis?
Recent clinical trials offer promising advancements in the treatment of juvenile idiopathic arthritis (JIA). Ustekinumab has shown potential as a therapeutic option, with Phase 3 and Phase 1 studies demonstrating its effectiveness. Additionally, Abatacept Injection underwent a Phase 3 trial to evaluate its efficacy in JIA patients. Upadacitinib also exhibited promise during its Phase 1 trial for treating this condition. Furthermore, Sarilumab SAR153191 (REGN88) demonstrated encouraging results in a Phase 2 study. These findings provide hope for improved management and outcomes for individuals living with JIA.
What juvenile idiopathic arthritis clinical trials were recently completed?
In August 2013, Bristol-Myers Squibb successfully concluded a clinical trial evaluating the effectiveness of Abatacept in treating juvenile idiopathic arthritis. This groundbreaking study offered valuable insights into potential treatment options for young patients dealing with this challenging condition.