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Small Molecule

JNJ-67484703 for Rheumatoid Arthritis

Phase 1
Waitlist Available
Research Sponsored by Janssen Research & Development, LLC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 24 weeks

Summary

This trial is testing JNJ-67484703, a specially designed antibody, in people with active rheumatoid arthritis. The treatment aims to help the immune system stop attacking its own tissues, which can reduce inflammation and symptoms.

Eligible Conditions
  • Rheumatoid Arthritis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 24 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Percentage of Participants with Abnormalities in Laboratory Parameters
Percentage of Participants with Abnormalities in Physical Examination
Percentage of Participants with Abnormalities in Vital Signs
+3 more
Secondary study objectives
Change from Baseline in Disease Activity Index Score 28 using C-reactive Protein (DAS28-CRP) at Week 12
Change in Magnitude and Duration of Cell Surface Expression Level of Receptors
Change in Number of T-lymphocyte Populations in Blood
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: JNJ-67484703Experimental Treatment1 Intervention
Participants will receive multiple doses of JNJ-67484703.
Group II: PlaceboPlacebo Group1 Intervention
Participants will receive multiple doses of placebo.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
JNJ-67484703
2021
Completed Phase 1
~50

Find a Location

Who is running the clinical trial?

Janssen Research & Development, LLCLead Sponsor
1,004 Previous Clinical Trials
6,398,263 Total Patients Enrolled
5 Trials studying Rheumatoid Arthritis
678 Patients Enrolled for Rheumatoid Arthritis
Janssen Research & Development, LLC Clinical TrialStudy DirectorJanssen Research & Development, LLC
770 Previous Clinical Trials
3,974,003 Total Patients Enrolled
2 Trials studying Rheumatoid Arthritis
278 Patients Enrolled for Rheumatoid Arthritis
~11 spots leftby Nov 2025
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