Popular Trials
Dietary Supplement
Calcium Fructoborate for Joint Discomfort
This trial tests a natural supplement called calcium fructoborate (CFB) to see if it can reduce joint pain in adults. The supplement may help by reducing inflammation in the body. Participants will take the supplement daily for a few months to measure changes in their joint discomfort and overall well-being. Calcium fructoborate (CFB) is a dietary supplement used for managing joint discomfort, leveraging the benefits of organic boron-containing molecules.
Vitamin
Vitamin D + Fish Oil for Health Improvement
This trial is studying whether taking daily dietary supplements of vitamin D3 or omega-3 fatty acids reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses.
Popular Filters
Trials for Osteoarthritis Patients
Behavioural Intervention
Physical Activity Program for Dementia and Chronic Pain
"This trial aims to create an exercise program for knee osteoarthritis that is suitable for individuals with memory problems. The study consists of two parts: Part 1 involves interviews with individuals aged
Selective Serotonin and Norepinephrine Reuptake Inhibitor
Pain Medication for Knee Osteoarthritis
This trial is for people with knee osteoarthritis pain at Northwestern University. It will last about 20 weeks and involve 180 participants. Participants will be split into three groups and given either dul
Corticosteroid
Corticosteroid Injection for Osteoarthritis
This trial found that a single intra-articular injection of triamcinolone acetonide was associated with decreased cartilage breakdown products in the early stages of OA, specifically in patients with higher degrees of synovitis.
Procedure
MFAT for Knee Osteoarthritis
This trial compares the effects of injecting processed fat tissue versus traditional steroid injections in patients with mild to moderate knee osteoarthritis. The fat is taken from the patient's body, slightly processed, and then injected into the knee to help heal and reduce pain and swelling.
Stem Cell Therapy
Stem Cell Transplantation + Arthroscopy for Knee Osteoarthritis
This trial is comparing two different treatments for patients with mild to moderate osteoarthritis. One treatment involves harvesting fat from the patient and transplanting stem cells from that fat, in addition to standard arthroscopic procedures. The other treatment is just the standard arthroscopic procedures without the stem cell transplant.
Trials for OA Patients
Behavioural Intervention
Physical Activity Program for Dementia and Chronic Pain
"This trial aims to create an exercise program for knee osteoarthritis that is suitable for individuals with memory problems. The study consists of two parts: Part 1 involves interviews with individuals aged
Selective Serotonin and Norepinephrine Reuptake Inhibitor
Pain Medication for Knee Osteoarthritis
This trial is for people with knee osteoarthritis pain at Northwestern University. It will last about 20 weeks and involve 180 participants. Participants will be split into three groups and given either dul
Corticosteroid
Corticosteroid Injection for Osteoarthritis
This trial found that a single intra-articular injection of triamcinolone acetonide was associated with decreased cartilage breakdown products in the early stages of OA, specifically in patients with higher degrees of synovitis.
Procedure
MFAT for Knee Osteoarthritis
This trial compares the effects of injecting processed fat tissue versus traditional steroid injections in patients with mild to moderate knee osteoarthritis. The fat is taken from the patient's body, slightly processed, and then injected into the knee to help heal and reduce pain and swelling.
Stem Cell Therapy
Stem Cell Transplantation + Arthroscopy for Knee Osteoarthritis
This trial is comparing two different treatments for patients with mild to moderate osteoarthritis. One treatment involves harvesting fat from the patient and transplanting stem cells from that fat, in addition to standard arthroscopic procedures. The other treatment is just the standard arthroscopic procedures without the stem cell transplant.
Trials With No Placebo
Behavioural Intervention
Physical Activity Program for Dementia and Chronic Pain
"This trial aims to create an exercise program for knee osteoarthritis that is suitable for individuals with memory problems. The study consists of two parts: Part 1 involves interviews with individuals aged
Procedure
MFAT for Knee Osteoarthritis
This trial compares the effects of injecting processed fat tissue versus traditional steroid injections in patients with mild to moderate knee osteoarthritis. The fat is taken from the patient's body, slightly processed, and then injected into the knee to help heal and reduce pain and swelling.
Stem Cell Therapy
Stem Cell Transplantation + Arthroscopy for Knee Osteoarthritis
This trial is comparing two different treatments for patients with mild to moderate osteoarthritis. One treatment involves harvesting fat from the patient and transplanting stem cells from that fat, in addition to standard arthroscopic procedures. The other treatment is just the standard arthroscopic procedures without the stem cell transplant.
Nonsteroidal Anti-inflammatory Drug
Diclofenac Cream 8% +1 More for Knee Injuries
Non-steroidal anti-inflammatory medication (NSAID) therapy is a mainstay treatment for joint pain and painful musculoskeletal disorders. Though this form of systemic therapy is highly effective, it causes substantial side effects including gastritis and gastric ulcer disease, renal impairment, hypertension, and thrombotic events. These types of oral medications are utilized by millions of Americans on a fairly regular basis in both over-the-counter preparations and prescription compounds. In recent years, topical preparations of NSAIDs have been used for localized pain as an alternate to oral administration with reported good analgesic efficacy. For example, they are often used for knee pain. There is little systemic absorption of NSAIDs with topical administration, and consequently less likelihood of systemic side effects. Though much less studied than oral NSAIDs, topical NSAID preparations are currently prescribed for a variety of arthritic and musculoskeletal types of pain. The best-studied commercially available products are diclofenac 1% compounds. Higher concentrations presumably provide higher tissue concentration leading to better and longer pain relief, along with a more prominent anti-inflammatory effect. The investigators will therefore compare the efficacy of available topical diclofenac 1% gel to that of diclofenac 8% cream. Specifically, the investigators propose to test the hypothesis that efficacy of topical diclofenac 8% exceeds that of diclofenac 1%, without any increase in systemic toxicity. One hundred six patients presenting to the Cleveland Clinic Pain Management Department for the treatment of knee pain will be randomly assigned to topical diclofenac cream 8% or diclofenac gel 1%, with the designated medication applied the symptomatic area of the knee over 6 weeks. Investigators will be blinded to treatment, and will evaluate pain relief and functional/disability status.
Behavioural Intervention
Manual Therapy +1 More for Chronic Knee Pain
This trial is looking at whether hands-on therapy and prescribed exercise can help manage and reduce knee pain, as well as improve physical benefits like balance, strength, and flexibility. There are some risks involved, but nothing serious.
View More Related Trials
Frequently Asked Questions
Introduction to knee pain
What are the top hospitals conducting knee pain research?
When it comes to finding innovative solutions for knee pain, several hospitals are leading the way with their ongoing clinical trials. Northwestern University in Chicago has two active trials focused on knee pain, demonstrating their commitment to understanding and treating this common ailment. Similarly, the Medical University of South carolina in Charleston is also actively studying knee pain through two ongoing trials. In Winter Park, Conquest Research is making strides with their two current knee pain trials as well. Additionally adding itself to this list is M D Anderson Cancer Center in Houston where they're currently conducting one trial focusing on alleviating knee pain; while Auburn University also contributes significantly by having one such experiment running at the moment.
These hospitals recognize the importance of addressing knee pain, which can significantly impact individuals' quality of life and mobility. Through these clinical trials, researchers aim to develop new treatments and interventions that may revolutionize how we manage and alleviate knee pain. By combining medical expertise with cutting-edge research techniques, these institutions contribute greatly not only towards improving treatment options but also enhancing our understanding of the mechanisms behind this widespread condition. With every study conducted at these esteemed facilities, we move closer toward a future where individuals suffering from chronic or acute knee pain can find relief and regain control over their lives
Which are the best cities for knee pain clinical trials?
When it comes to knee pain clinical trials, several cities offer notable research opportunities. Hartford, Connecticut has 3 active trials investigating Autologous Bone Grafting and other treatments. Chicago, Illinois also has 3 ongoing studies focusing on X0002, SL-1002, and additional interventions. Houston, Texas follows closely with 2 active trials exploring Group 1 (standard steroid injection), Wireless neuromodulation technology, and more. Additionally, New york City and La Mesa in California each have 2 active trials examining innovative approaches such as Dorsal Root Ganglion Stimulation and Resiniferatoxin for knee pain management. These cities contribute to the advancement of knowledge and potential treatment options for individuals suffering from knee pain.
Which are the top treatments for knee pain being explored in clinical trials?
Clinical trials are actively investigating various treatments to alleviate knee pain. Among the forefront contenders are:
- Platelet-rich plasma (PRP): A technique that uses a patient's own blood components to promote healing and reduce inflammation.
- Hyaluronic acid injections: These provide lubrication and cushioning within the knee joint, potentially relieving discomfort.
- Mesenchymal stem cells: Derived from bone marrow or adipose tissue, these cells have shown promise in promoting tissue regeneration and reducing inflammation in early studies of knee pain management. These innovative approaches hold great potential for improving the lives of individuals suffering from knee pain, with ongoing research striving towards more effective treatment options.
What are the most recent clinical trials for knee pain?
Exciting advancements in the field of knee pain management have emerged through recent clinical trials. One notable study explored the effectiveness of a SAM ultrasound device and diclofenac patch in alleviating knee pain, offering potential relief to those suffering from this common ailment. Additionally, researchers investigated the impact of various treatments such as knee osteoarthritis, SL-1002, resiniferatoxin, and 6% aqueous phenol on reducing knee pain. With these innovative trials paving the way forward for improved treatment options, individuals burdened by knee pain can anticipate promising developments on the horizon.
What knee pain clinical trials were recently completed?
Recently, several clinical trials focusing on knee pain have been successfully completed, bringing hope for those suffering from this debilitating condition. These trials include a study sponsored by Massachusetts General Hospital that investigated the effectiveness of a novel drug in alleviating knee pain. Another trial conducted by Johns Hopkins University explored the potential benefits of non-invasive treatments for knee pain management. Additionally, researchers at Stanford University recently completed a trial examining the efficacy of physical therapy interventions in reducing knee pain and improving function. These significant advancements signify progress in addressing knee pain and offer prospects for improved quality of life for patients experiencing this common issue.