Popular Trials
Cell Therapy
PSC-01 for Osteoarthritis
The objective of this clinical study is to evaluate the safety of an intraarticular injection of an investigational biologic product (IBP), PSC-01, the patient's own adipose-derived stromal vascular fraction cells (SVF) extracted from a lipoaspirate sample, to treat the pain of osteoarthritis in a single knee. The secondary objective is to get initial data on efficacy of the PSC-01.
Platelet-Rich Plasma
Platelet-Rich Plasma vs Hyaluronic Acid for Osteoarthritis
This trial is testing whether platelet-rich plasma (PRP) is more effective than hyaluronic acid (HA) in treating knee osteoarthritis, as measured by changes in cartilage thickness and pain/function scores. Approximately 100 subjects will be treated at NorthShore University HealthSystem.
Stem Cell Therapy
Stem Cell Transplantation + Arthroscopy for Knee Osteoarthritis
This trial is comparing two different treatments for patients with mild to moderate osteoarthritis. One treatment involves harvesting fat from the patient and transplanting stem cells from that fat, in addition to standard arthroscopic procedures. The other treatment is just the standard arthroscopic procedures without the stem cell transplant.
Popular Filters
Trials for OA Patients
Corticosteroid
Methylprednisolone for Knee Arthritis
"This trial is testing if a specific steroid medication, methylprednisolone, can improve patient outcomes after knee replacement surgery. The steroid will be given in decreasing doses over time to see if it helps
Selective Serotonin and Norepinephrine Reuptake Inhibitor
Pain Medication for Knee Osteoarthritis
This trial is for people with knee osteoarthritis pain at Northwestern University. It will last about 20 weeks and involve 180 participants. Participants will be split into three groups and given either dul
Behavioural Intervention
Dietary Interventions for Osteoarthritis Pain
This trial will investigate the efficacy of low-carb diets to reduce knee OA pain, with an emphasis on racial differences and interactions with biopsychosocial factors. #OA #RacialDisparities #PainRelief #LCD
Behavioral Intervention
Non-Surgical Management for Knee Osteoarthritis
This trial will compare two different ways of treating knee osteoarthritis. All subjects will receive a standardized approach recommended by the Department of Defense and Veterans Administration. Follow-up will occur over a 1 year period.
Procedure
Pulsed Radiofrequency vs Physical Therapy for Knee Osteoarthritis
This trial is testing if PRF, a treatment using short bursts of radio waves, can reduce chronic knee pain in adults with osteoarthritis. The study aims to see if PRF provides pain relief by affecting the nerves in the knee. Pulsed radiofrequency (PRF) has been used in various studies to treat knee pain originating from osteoarthritis, showing potential in pain relief and functional improvement.
Trials for Osteoarthritis Patients
Corticosteroid
Methylprednisolone for Knee Arthritis
"This trial is testing if a specific steroid medication, methylprednisolone, can improve patient outcomes after knee replacement surgery. The steroid will be given in decreasing doses over time to see if it helps
Selective Serotonin and Norepinephrine Reuptake Inhibitor
Pain Medication for Knee Osteoarthritis
This trial is for people with knee osteoarthritis pain at Northwestern University. It will last about 20 weeks and involve 180 participants. Participants will be split into three groups and given either dul
Behavioural Intervention
Dietary Interventions for Osteoarthritis Pain
This trial will investigate the efficacy of low-carb diets to reduce knee OA pain, with an emphasis on racial differences and interactions with biopsychosocial factors. #OA #RacialDisparities #PainRelief #LCD
Behavioral Intervention
Non-Surgical Management for Knee Osteoarthritis
This trial will compare two different ways of treating knee osteoarthritis. All subjects will receive a standardized approach recommended by the Department of Defense and Veterans Administration. Follow-up will occur over a 1 year period.
Procedure
Pulsed Radiofrequency vs Physical Therapy for Knee Osteoarthritis
This trial is testing if PRF, a treatment using short bursts of radio waves, can reduce chronic knee pain in adults with osteoarthritis. The study aims to see if PRF provides pain relief by affecting the nerves in the knee. Pulsed radiofrequency (PRF) has been used in various studies to treat knee pain originating from osteoarthritis, showing potential in pain relief and functional improvement.
Phase 3 Trials
Botanical Preparation
Myalgesinâ„¢ for Osteoarthritis
This trial tests Myalgesin, a natural supplement made from celery seeds, Boswellia resin, and Phellodendron bark. It aims to help people with knee osteoarthritis by reducing inflammation and blocking enzymes that cause pain, thereby improving joint function and mobility.
Procedure
MFAT for Knee Osteoarthritis
This trial compares the effects of injecting processed fat tissue versus traditional steroid injections in patients with mild to moderate knee osteoarthritis. The fat is taken from the patient's body, slightly processed, and then injected into the knee to help heal and reduce pain and swelling.
Non-Surgical Interventions for Knee Osteoarthritis
This trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA. The results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Stem Cell Therapy
Stem Cell Treatment for Knee Osteoarthritis
This trial is testing a new treatment that uses cells from a patient's own fat to help repair knee damage in people with knee osteoarthritis. The cells are injected into the knee to reduce pain and improve joint function. This type of therapy has been increasingly studied and used for treating knee osteoarthritis due to its potential to reduce pain and improve joint function.
Topical Analgesic
Biofreeze 4 % Topical Gel for Osteoarthritis
Knee osteoarthritis (OA) is a progressive disease that can be accompanied by considerable joint pain and dysfunction. It is a goal in the medical field to find effective treatments for knee OA that are non-interventional, have minor or no negative side effects, and are relatively easy to administer for the patient and health care professionals. Biofreeze, a topical analgesic containing menthol, is an easily accessible gel, with no known serious negative side effects. If the application of Biofreeze can reduce the pain and dysfunction associated with knee OA, it could be an effective treatment for patients. The objective of the study is to assess how 4 weeks of Biofreeze application to a knee affected by OA effects pain and dysfunction associated with the disease.
Cannabinoid
CBD for Knee Osteoarthritis
This trial is testing if CBD tablets that dissolve in the mouth can reduce pain and improve function in people with knee osteoarthritis. The study targets patients who are already doing physiotherapy and home exercises. CBD is thought to work by interacting with the body's system that controls pain and inflammation. CBD is a non-euphoric component of cannabis that has shown potential in relieving pain and reducing inflammation in osteoarthritis.
Trials With No Placebo
Corticosteroid
Methylprednisolone for Knee Arthritis
"This trial is testing if a specific steroid medication, methylprednisolone, can improve patient outcomes after knee replacement surgery. The steroid will be given in decreasing doses over time to see if it helps
Behavioural Intervention
Dietary Interventions for Osteoarthritis Pain
This trial will investigate the efficacy of low-carb diets to reduce knee OA pain, with an emphasis on racial differences and interactions with biopsychosocial factors. #OA #RacialDisparities #PainRelief #LCD
Behavioral Intervention
Non-Surgical Management for Knee Osteoarthritis
This trial will compare two different ways of treating knee osteoarthritis. All subjects will receive a standardized approach recommended by the Department of Defense and Veterans Administration. Follow-up will occur over a 1 year period.
Procedure
Pulsed Radiofrequency vs Physical Therapy for Knee Osteoarthritis
This trial is testing if PRF, a treatment using short bursts of radio waves, can reduce chronic knee pain in adults with osteoarthritis. The study aims to see if PRF provides pain relief by affecting the nerves in the knee. Pulsed radiofrequency (PRF) has been used in various studies to treat knee pain originating from osteoarthritis, showing potential in pain relief and functional improvement.
Corticosteroid
Methylprednisolone +1 More for Osteoarthritis
Do differences exist between patients who receive a single intra-articular injection of corticosteroid versus patients who receive a single intra-articular injection of hyaluronic acid for the treatment of knee osteoarthritis at 1, 3 and 6 weeks, and 3 and 6 months post injection?
Trials Offering Remuneration
Procedure
PRP and NSAIDs for Knee Osteoarthritis
This trial aims to see if a combination of drug therapy and Platelet-Rich Plasma injections can reduce knee pain and improve physical function in individuals with osteoarthritic knee joints. Participants will be randomly
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Frequently Asked Questions
Introduction to knee osteoarthritis
What are the top hospitals conducting knee osteoarthritis research?
When it comes to advancing research and finding innovative treatments for knee osteoarthritis, several hospitals are making significant contributions. In Seattle, the University of Washington is at the forefront with three ongoing clinical trials dedicated to this condition. While they may not have conducted any previous knee osteoarthritis trials, their active involvement demonstrates a commitment to improving patient outcomes. Similarly, in Salt Lake City, the University of Utah is also conducting three active knee osteoarthritis trials, signaling their dedication to exploring new treatment options. Moving towards BioSolutions Clinical Research Center in La Mesa and Affinity Health in Oak Brook both hosting two ongoing investigations related to this condition; each institution aims at creating breakthroughs that can make a substantial impact on patients' lives. Lastly joining them is Healthcare Research Network located in Hazelwood where multiple efforts are underway to understand and develop innovative approaches against knee osteoarthritis.
Knee osteoarthritis affects millions of people worldwide and can cause pain, stiffness, and reduced mobility. By actively engaging in these clinical trials for knee osteoarthritis across various locations throughout the United States healthcare landscape offers hope for those suffering from this degenerative joint disease.
Which are the best cities for knee osteoarthritis clinical trials?
In the realm of knee osteoarthritis clinical trials, several cities emerge as prominent hubs for research. La Mesa, California leads the way with 8 active trials investigating treatments like Lorecivivint, canakinumab, and JointStem. San Antonio, Texas also boasts 8 ongoing studies focusing on interventions such as Lorecivivint, DoD/VA CPG Core Set + PT, and Microfragmented Adipose Tissue (Mfat). Chicago, Illinois follows closely behind with 7 active trials delving into potential treatments like Lorecivivint, DFV890, and Naproxen 500 Mg. Together these cities provide individuals suffering from knee osteoarthritis access to cutting-edge clinical trials that pave the path towards advancements in treatment options and improved quality of life.
Which are the top treatments for knee osteoarthritis being explored in clinical trials?
Clinical trials are at the forefront of advancing treatment options for knee osteoarthritis. Among the top treatments being explored in these trials are:
- Platelet-rich plasma (PRP): A therapy that utilizes a concentrated dose of platelets from the patient's own blood to stimulate healing and reduce inflammation.
- Mesenchymal stem cells (MSCs): Stem cell-based therapies that have shown promise in promoting tissue regeneration and reducing pain.
- Hyaluronic acid injections: Injections of hyaluronic acid into the affected joint, providing lubrication and cushioning to alleviate symptoms. These treatments offer hope for patients with knee osteoarthritis, potentially improving their quality of life by addressing pain and mobility issues.
What are the most recent clinical trials for knee osteoarthritis?
Recent clinical trials offer hope for individuals suffering from knee osteoarthritis. Group A TA 40 mg, a Phase 4 trial, has shown promise in providing relief for those with this degenerative joint disease. Additionally, GNSC-001 (low dose), Kenalog with 0ml bupivacaine, RHH646, and Microfragmented Adipose Tissue (Mfat) have also demonstrated potential benefits as treatment options for knee osteoarthritis during their respective phases of research. These studies mark significant strides in the quest to improve the quality of life for patients grappling with this debilitating condition.
What knee osteoarthritis clinical trials were recently completed?
Several recent clinical trials have focused on advancing our understanding and treatment of knee osteoarthritis. Notably, a trial sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) investigating the efficacy of Lasmiditan in managing this condition was recently completed. Additionally, another significant study led by the Hospital for Special Surgery examined the potential benefits of Platelet-Rich Plasma (PRP) injections for knee osteoarthritis patients. These advancements provide valuable insights into new therapeutic approaches that may help alleviate symptoms and improve quality of life for individuals living with knee osteoarthritis.