Popular Trials
Vitamin Supplement
Vitamin D drops for Obesity
Recruiting3 awardsPhase 4
New York, New York
The discovery that the vitamin D receptor is expressed in more than 30 tissues indicates that the physiologic functions of vitamin D are much broader than its well-known role in the regulation of calcium absorption and bone metabolism. There is evidence that vitamin D is involved in the pathogenesis of cancer, cardiovascular disease, multiple sclerosis, and type I diabetes. Recent epidemiological evidence points to a strong association between vitamin D insufficiency and insulin resistance, the metabolic syndrome, and type II diabetes. The investigators would like to examine the role of vitamin D in the development of insulin resistance in overweight children and adolescents, which represent a high risk population for cardiovascular and metabolic complications. The investigators propose a prospective randomized clinical trial of vitamin D supplementation in overweight, insulin resistant, vitamin D deficient children. The investigators objective is to assess if changes in insulin resistance, fasting lipid profiles, blood pressure, and inflammatory markers occur in these patients post treatment with vitamin D. Additionally, concomitant changes in calcium and bone metabolism after vitamin D treatment will be evaluated. This is because, contrary to adults, the optimal vitamin D concentrations that regulate calcium and bone metabolism have not been established in pediatrics.
Vitamin
Vitamin D + Fish Oil for Health Improvement
Recruiting1 award
Boston, Massachusetts
This trial is studying whether taking daily dietary supplements of vitamin D3 or omega-3 fatty acids reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses.
Vitamin Supplement
Vitamin D3 for Thalassemia
Recruiting4 awardsPhase 4
New York, New York
This trial tests different doses of vitamin D3 in children and adults with Thalassemia Major to see how it affects their blood vitamin D levels and urine calcium levels. People with this condition often have low vitamin D and weak bones. The study aims to find the best dose to improve their health without causing too much calcium in their urine. Vitamin D3 has been studied for its effects on bone health and vitamin D levels in patients with thalassemia major, who often suffer from vitamin D deficiency and related complications.
Procedure
Bioimpedance for Peritoneal Dialysis
Recruiting1 awardPhase 2
Hamilton, Ontario
The main purpose of this study is to compare the effects of using bio-impedance analysis to guide management of fluid status versus routine clinical care on heart structure. In addition, Vitamin D is being assessed to determine its effect on heart structure.
Omega-3 Fatty Acids
DHA/EPA for Frailty
Recruiting2 awardsPhase 4
Farmington, Connecticut
The purpose of this study is to examine the effects of essential fatty acid (EFA) supplementation on bone metabolism and frailty in postmenopausal women. The overall hypothesis is that EFA supplementation, via its immunoregulatory and anti-inflammatory activity, will decrease bone turnover, decrease prostaglandins and cytokines associated with bone metabolism and frailty, and change physical outcome measures associated with frailty in postmenopausal women with low bone mass and frailty.
Vitamin
Vitamin D for Premature Infants
Recruiting0 awards7 criteria
Houston, Texas
This trial is testing whether a vitamin D supplement in a transitional formula given to premature babies will lead to higher serum levels of vitamin D at 52 weeks PMA, and whether any infants will have a serum vitamin D level below 20 ng/mL.
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Phase 3 Trials
Vitamin Supplement
Vitamin D3 + Omega-3 for Atrial Fibrillation
Recruiting1 awardPhase 3
Boston, Massachusetts
This trial is looking at whether taking daily supplements of vitamin D3 or omega-3 fatty acids reduces the risk of developing cancer, heart disease, and stroke. They will also be looking at whether these agents might impact the development of atrial fibrillation and explore effects on arrhythmic death.
Trials With No Placebo
1 for Prostate Cancer
Recruiting1 awardPhase 2
Toronto, Ontario
This trial gives men different doses of vitamin D3 who are scheduled for prostate removal due to cancer. Vitamin D3 might help by turning into a form that slows down cancer cell growth in the prostate. Vitamin D3, through its active form 1,25-dihydroxyvitamin D3, has been shown to inhibit prostate cancer cell growth and promote differentiation.
Anabolic Agent
Teriparatide for Osteoporosis
Recruiting3 awardsPhase 2
West Haverstraw, New York
Osteoporosis is a disease that affects millions of individuals in the United States and abroad. It leads to decreased bone mass and causes an increased risk of fracture. This study will compare continuous versus cyclic treatment with teriparatide combined with alendronate, another drug for osteoporosis, or teriparatide alone in women with osteoporosis.
Vitamin
Vitamin D3 for Vitamin D Deficiency
Recruiting3 awards6 criteria
New York, New York
The purpose of this study is to investigate the effect of two different doses of vitamin D3 (2000 IU vs. 4000 IU) on serum 25-hydroxyvitamin D (25OHD) levels in patients with hepatocellular carcinoma on the liver transplant list. The study will help determine the dose of vitamin D3 that is required for patients with liver cancer to reach a normal level of 25OHD in the blood.
Dietary Supplement
Omega 3 +3 More for Dry Eye Syndrome
Recruiting3 awardsPhase 4
Conifer, Colorado
Dry eye disease (DED) is a common but often inadequately treated disease of the tears and surface of the eye. It can cause poor vision and chronic pain and is more frequent with increasing age. The 1995 Report of the National Eye Institute/Industry Workshop on Clinical Trials in Dry Eye defined dry eye as "a disorder of the tear film due to tear deficiency or excessive evaporation, which causes damage to the interpalpebral ocular surface and is associated with symptoms of ocular discomfort". The International Dry Eye Work Shop (DEWS) committee subsequently defined dry eye as "a multi-factorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by increased osmolarity of the tear film and inflammation of the ocular surface." Typically, symptoms associated with dry eye disease include ocular burning, foreign body sensation (sand or grit), photophobia (light sensitivity), and other symptoms that result in overall long term discomfort in patients. The proposed eight week feasibility study if dry eye subjects confirmed elevated osmolarity and symptoms respond to nutritional therapy.
Vitamin D Supplement
Cholecalciferol for Chronic Kidney Disease
Recruiting3 awards1 criteria
Memphis, Tennessee
To determine whether or not chronic kidney disease (CKD), stages III-V and ESRD , is associated with altered vitamin D metabolism related to fibroblast growth factor-23 (FGF-23) stimulation of Cyp24 and whether they have resistance to elevations of 25 Hydroxyvitamin D (25(OH)D3) after cholecalciferol supplementation. To determine if such resistance is related to enhanced catabolism of (25(OH)related to elevated levels of FGF-23.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.