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Janus Kinase (JAK) Inhibitor

Ritlecitinib 20 mg for Alopecia Areata

Phase 1
Waitlist Available
Research Sponsored by Pfizer
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 (pre-dose), 0.5, 1, 3 and 8 hours post-dose on day 7
Awards & highlights

Summary

This trial tests Ritlecitinib in children with severe hair loss. It aims to understand how the medicine is processed by the body and its effects. Blood samples will be taken to gather this information. The goal is to find the right dose for future studies. Ritlecitinib has shown promising results in treating alopecia areata in previous studies.

Eligible Conditions
  • Alopecia Areata

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 (pre-dose), 0.5, 1, 3 and 8 hours post-dose on day 7
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 (pre-dose), 0.5, 1, 3 and 8 hours post-dose on day 7 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Area under the plasma concentration time profile over the dosing interval 24 hrs, at steady-state (AUC24) on Day 7
Secondary study objectives
Apparent Oral Clearance (CL/F)
Apparent Volume of Distribution (Vz/F)
Change from baseline in interferon gamma, IP-10 and lymphocyte subsets (T cell, B cell, and NK cells)
+12 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Ritlecitinib 20 mgExperimental Treatment1 Intervention
Participants will receive Ritlecitinib 20 mg by mouth once daily (QD).
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ritlecitinib 20 mg
2023
Completed Phase 1
~20

Find a Location

Who is running the clinical trial?

PfizerLead Sponsor
4,625 Previous Clinical Trials
14,284,179 Total Patients Enrolled
14 Trials studying Alopecia Areata
86,469 Patients Enrolled for Alopecia Areata
Pfizer CT.gov Call CenterStudy DirectorPfizer
3,518 Previous Clinical Trials
11,458,755 Total Patients Enrolled
7 Trials studying Alopecia Areata
3,362 Patients Enrolled for Alopecia Areata
~6 spots leftby Sep 2025
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