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Cardiac Regenerative Therapy

Allogeneic Cardiosphere-Derived Cells for Heart Failure (DYNAMIC Trial)

Phase 1
Waitlist Available
Led By Rajendra (Raj) Makkar, MD
Research Sponsored by Capricor Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

To determine the safety profile of CAP-1002 administered by multi-vessel intracoronary infusion in subjects with DCM. The study will further explore safety and exploratory efficacy endpoints of CAP-1002.

Eligible Conditions
  • Heart Failure
  • Non Ischemic Cardiomyopathy
  • Dilated Cardiomyopathy
  • Cardiomyopathy

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Allogeneic Cardiosphere-Derived CellsExperimental Treatment1 Intervention
The Phase I study consists of a Phase Ia portion and a Phase Ib portion. The Phase Ia portion (N=14 subjects) consists of an open-label, single-arm, study design. The potentially conducted Phase Ib portion of the study (N=28 subjects) consists of a double-blind, randomized, placebo-controlled study design. The Phase Ia portion is an open-label, dose escalation of Allogeneic Cardiosphere-Derived Cells (CDCs).
Group II: PlaceboPlacebo Group1 Intervention
The placebo study arm only applies to the Phase Ib portion of the study design. The Phase Ia portion (N=14 subjects) consists of an open-label, single-arm, study design. The potentially conducted Phase Ib portion of the study (N=28 subjects) consists of a double-blind, randomized, placebo-controlled study design.

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH
2,765 Previous Clinical Trials
8,133,469 Total Patients Enrolled
35 Trials studying Heart Failure
7,844 Patients Enrolled for Heart Failure
Capricor Inc.Lead Sponsor
11 Previous Clinical Trials
446 Total Patients Enrolled
2 Trials studying Heart Failure
22 Patients Enrolled for Heart Failure
Cedars-Sinai Medical CenterOTHER
509 Previous Clinical Trials
165,871 Total Patients Enrolled
11 Trials studying Heart Failure
9,999 Patients Enrolled for Heart Failure
~4 spots leftby Sep 2025
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