Advanced Radiation Techniques for Stem Cell Transplant Recipients

Phase 1

Waitlist Available

Led By Savita V Dandapani

Research Sponsored by City of Hope Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 1 year post transplant

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing how well two different radiation therapy techniques work to reduce doses to the lung compared to the standard method. The hope is that this will improve survival and decrease long term lung side effects in patients undergoing stem cell transplant.

Who is the study for?

This trial is for patients with acute leukemia or myelodysplastic syndrome who are suitable for stem cell transplant and total body irradiation (TBI). They must have a performance status indicating they can care for themselves, agree to use contraception, and not be pregnant. Prior treatments are allowed if completed two weeks before TBI.

What is being tested?

The study tests whether advanced radiation techniques like VMAT or tomotherapy can better protect the lungs from damage during TBI compared to standard methods in patients undergoing donor stem cell transplants. The goal is to improve survival rates and reduce long-term lung complications.

What are the potential side effects?

While specific side effects aren't listed, potential risks include those commonly associated with radiation therapy such as skin irritation, fatigue, nausea, and increased risk of infection due to lowered immune response post-transplant.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 1 year post transplant

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 1 year post transplant

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year post transplant for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Completion of all fractions of intensity-modulated radiation therapy (IMRT) total body irradiation (TBI) (volume modulated arc therapy or tomotherapy)

Secondary study objectives

Dose homogeneity for all target and non-target structures

Non-relapse mortality

Rate of adverse events with IMRT TBI

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