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Proton Pump Inhibitor

Treatment Sequence 3 for Healthy Subjects

Phase 1
Waitlist Available
Research Sponsored by Phathom Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

This trial is testing a new way to take vonoprazan, a medicine that reduces stomach acid, by sprinkling it on food like pudding or applesauce. The study involves healthy participants to see how well the body absorbs the medicine in this new form compared to the traditional tablet. Vonoprazan helps treat conditions like heartburn by blocking acid production in the stomach.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2017 Phase 4 trial • 3 Patients • NCT03116841
33%
Viral upper respiratory tract
33%
Gastrointestinal disorder
100%
80%
60%
40%
20%
0%
Study treatment Arm
Vonoprazan 20mg

Trial Design

3Treatment groups
Experimental Treatment
Group I: Treatment Sequence 3Experimental Treatment1 Intervention
Participants assigned to Treatment Sequence 3 will receive vonoprazan 20 mg as a sprinkle capsule on 1 tablespoon of applesauce on Day 1 of Treatment Period 1, vonoprazan 20 mg as a tablet on Day 1 of Treatment Period 2, and vonoprazan 20 mg as a sprinkle capsule on 1 tablespoon of pudding on Day 1 of Treatment Period 3.
Group II: Treatment Sequence 2Experimental Treatment1 Intervention
Participants assigned to Treatment Sequence 2 will receive vonoprazan 20 mg as a tablet on Day 1 of Treatment Period 1, vonoprazan 20 mg as a sprinkle capsule on 1 tablespoon of pudding on Day 1 of Treatment Period 2, and vonoprazan 20 mg as a sprinkle capsule on 1 tablespoon of applesauce on Day 1 of Treatment Period 3.
Group III: Treatment Sequence 1Experimental Treatment1 Intervention
Participants assigned to Treatment Sequence 1 will receive vonoprazan 20 mg as a sprinkle capsule on 1 tablespoon of pudding on Day 1 of Treatment Period 1, vonoprazan 20 mg as a sprinkle capsule on 1 tablespoon of applesauce on Day 1 of Treatment Period 2, and vonoprazan 20 mg as a tablet on Day 1 of Treatment Period 3.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Vonoprazan
2019
Completed Phase 4
~12720

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Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Phathom Pharmaceuticals, Inc.Lead Sponsor
10 Previous Clinical Trials
3,428 Total Patients Enrolled
Medical DirectorStudy DirectorPhathom Pharmaceuticals
2,834 Previous Clinical Trials
8,079,753 Total Patients Enrolled
~8 spots leftby Sep 2025
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