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glucagon s.c. injection and atenolol tablet for Healthy Subjects

N/A
Waitlist Available
Led By Michael O Thorner
Research Sponsored by University of Virginia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
All Individual Drugs Already Approved
Approved for 10 Other Conditions

Summary

Glucagon has been used for decades as a test of growth hormone (GH) reserve. The pathway by which GH is stimulated by glucagon is not established. Acyl ghrelin has been shown to increase GH levels and to be stimulated by an increase in adrenergic activity. The proposed study will test the concept that with the fall in blood glucose it is likely that there is a sympathetic discharge which contributes to the increase in acyl ghrelin and indirectly leads to the increase in GH and cortisol.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

4Treatment groups
Experimental Treatment
Group I: glucagon s.c. injection and placebo tabletExperimental Treatment2 Interventions
1 mg glucagon s.c. injection and one placebo tablet (preceded by one placebo tablet per day at 0900h for two days before admission).
Group II: glucagon s.c. injection and atenolol tabletExperimental Treatment2 Interventions
1 mg glucagon s.c. injection and 100 mg atenolol tablet
Group III: Saline s.c. injection and placebo tabletExperimental Treatment2 Interventions
Saline s.c. injection and one placebo tablet (preceded by one placebo tablet per day at 0900h for two days before admission).
Group IV: Saline s.c. injection and atenolol tabletExperimental Treatment2 Interventions
Saline s.c. injection and 100 mg atenolol tablet
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Glucagon
FDA approved
Sodium chloride
FDA approved
Placebo
1995
Completed Phase 3
~2670
Atenolol
FDA approved

Find a Location

Who is running the clinical trial?

Novo Nordisk A/SIndustry Sponsor
1,551 Previous Clinical Trials
2,444,899 Total Patients Enrolled
University of VirginiaLead Sponsor
781 Previous Clinical Trials
1,315,664 Total Patients Enrolled
Michael O ThornerPrincipal InvestigatorUniversity of Virginia
~0 spots leftby Nov 2025
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