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Apple vs Cranberry Juice for UTI Prevention in Healthy Women

N/A
Waitlist Available
Led By Liwei Gu, PhD
Research Sponsored by University of Florida
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Healthy women participants;
Healthy women participants
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to 21 days of each intervention
Awards & highlights

Summary

This trial found that some women who drink cranberry juice are less likely to get UTIs, but they don't know why. It could be because of the way the body processes the juice, which varies from person to person.

Who is the study for?
This trial is for healthy women with a Body Mass Index (BMI) between 18.5 and 29.9, weighing at least 110 pounds. It's not suitable for those on medications that could affect the study results, pregnant or breastfeeding women, individuals with significant health issues, smokers, or frequent alcohol users.
What is being tested?
The study is examining how apple juice and cranberry juice might influence urinary tract infection (UTI) susceptibility in women by looking at their gut microbiome. The goal is to understand why cranberry juice has had mixed results in preventing UTIs.
What are the potential side effects?
Since the interventions involve common beverages like apple and cranberry juice, side effects are expected to be minimal but may include mild digestive discomfort or allergic reactions in rare cases.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am a healthy woman.
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I am a healthy woman.
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I weigh at least 110 pounds.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to 21 days of each intervention
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 21 days of each intervention for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in the unrinary anti-adhesion activity of UTI susceptible women
Secondary study objectives
Determine the compositional differences of gut microbiome in responders and non-responders after the cranberry juice intake
Identify anti-adhesion urinary biomarkers in responders versus non-responders after the cranberry juice intake

Trial Design

2Treatment groups
Experimental Treatment
Group I: Cranberry juice consumptionExperimental Treatment1 Intervention
Participants deemed as responders and non-responders will be given 20-30 oz (590-885 mL) of cranberry juice daily for 3 weeks.
Group II: Apple juice consumptionExperimental Treatment1 Intervention
Participants deemed as responders and non-responders will be given 20-30 oz (590-885 mL) apple juice with matching sugar and calories daily for 3 weeks.

Find a Location

Who is running the clinical trial?

University of FloridaLead Sponsor
1,380 Previous Clinical Trials
762,235 Total Patients Enrolled
United States Department of Agriculture (USDA)FED
100 Previous Clinical Trials
286,519 Total Patients Enrolled
Liwei Gu, PhDPrincipal InvestigatorUniversity of Florida
6 Previous Clinical Trials
180 Total Patients Enrolled

Media Library

Cranberry juice Clinical Trial Eligibility Overview. Trial Name: NCT05065008 — N/A
Healthy Subjects Research Study Groups: Cranberry juice consumption, Apple juice consumption
Healthy Subjects Clinical Trial 2023: Cranberry juice Highlights & Side Effects. Trial Name: NCT05065008 — N/A
Cranberry juice 2023 Treatment Timeline for Medical Study. Trial Name: NCT05065008 — N/A
~36 spots leftby Aug 2025
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