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Nicotinic Acetylcholine Receptor Agonist

Cytisine + Video Messaging for Smoking Cessation (PREVENT Trial)

Phase 3
Recruiting
Led By Flavia Kessler Borges, Dr.
Research Sponsored by Population Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
are ≥18 years of age
are a current smoker (i.e., smoked at least 10 cigarettes per day during the previous year and had no period of smoking abstinence longer than 6 months) and not currently using any smoking cessation treatment and
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Summary

This trial, called PREVENT, is studying the effects of cytisine versus a placebo, as well as the effects of video messaging versus standard care, on people who are about to have surgery.

Who is the study for?
The PREVENT trial is for adults over 18 who smoke at least 10 cigarettes daily, haven't quit for more than 6 months in the past year, and are scheduled for surgery within the next 1-28 days. Participants must not be on smoking cessation treatments but should have a smartphone with an active data plan.
What is being tested?
This study tests if cytisine (a plant-based compound) helps people quit smoking better than a placebo. It also checks if video messages can boost quitting success compared to usual care. Patients will be randomly assigned to receive either cytisine or placebo, and video messaging support or standard care.
What are the potential side effects?
Cytisine may cause mild side effects like nausea, headache, dry mouth, and trouble sleeping. Video messaging has no physical side effects but could affect privacy or lead to increased screen time.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I currently smoke at least 10 cigarettes daily and haven't tried to quit for more than 6 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Smoking Cessation
Secondary study objectives
6 month continuous abstinence rate
7-day point-prevalence abstinence at 30 days
7-day point-prevalence abstinence at 56 days
+15 more
Other study objectives
Health services utilization-related costs
Health-related quality of life (HRQoL)

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Cytisine and Video MessagingExperimental Treatment2 Interventions
Administration of cytisine (pharmaceutical support) to patients on a set dose schedule with behavioural support through video messaging.
Group II: Cytisine and No Video MessagingActive Control1 Intervention
Administration of cytisine (pharmaceutical support) to patients on a set dose schedule with behavioural support according to standard care such as a phone number for a self-help line.
Group III: Placebo and No Video MessagingActive Control1 Intervention
Administration of placebo (inactive drug) to patients on a set dose schedule behavioural support according to standard care such as a phone number for a self-help line.
Group IV: Placebo and Video MessagingPlacebo Group1 Intervention
Administration of placebo (inactive drug) to patients on a set dose schedule with behavioural support through video messaging.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cytisine
2017
Completed Phase 3
~1710

Find a Location

Who is running the clinical trial?

Population Health Research InstituteLead Sponsor
161 Previous Clinical Trials
710,414 Total Patients Enrolled
Flavia Kessler Borges, Dr.Principal InvestigatorPopulation Health Research Institute
Sandra Ofori, Dr.Principal InvestigatorPopulation Health Research Institute
~1147 spots leftby Jul 2026
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