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Tyrosine Kinase Inhibitor

Sorafenib and Vinorelbine for Breast Cancer

Phase 1 & 2
Waitlist Available
Led By Lawrence Panasci
Research Sponsored by McGill University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Summary

This is a phase IB/II trial of sorafenib, a new tyrosine kinase inhibition of multiple genes that is active against renal cancer, plus vinorelbine, a chemotherapy agent active in breast cancer. The investigators are combining these 2 drugs in order to determine if the investigators can increase the activity of vinorelbine in metastatic breast cancer patients. Patients with measurable metastatic breast cancer without previous chemotherapy for metastatic disease are eligible for the protocol. They will be treated with 2 different dose levels of sorafenib in order to determine the most tolerable dose.

Eligible Conditions
  • Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

1Treatment groups
Experimental Treatment
Group I: Sorafenib and VinorelbineExperimental Treatment1 Intervention

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Who is running the clinical trial?

McGill UniversityLead Sponsor
403 Previous Clinical Trials
1,018,023 Total Patients Enrolled
5 Trials studying Breast Cancer
210 Patients Enrolled for Breast Cancer
Lawrence PanasciPrincipal InvestigatorMcGill University
~2 spots leftby Sep 2025
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