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Opioid Analgesic

Spinal Morphine for Anesthesia

Phase 4
Recruiting
Led By Engy T Said, MD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-operative day 0, 1, 2, 3, 4, 14, 30
Awards & highlights

Summary

This trial tests if adding ESP catheters to the current pain management plan improves pain relief after liver surgery. The study targets adults having liver surgery, as this procedure is very painful and current methods don't last long enough. ESP catheters provide continuous pain relief by blocking pain signals near the spine. This method has shown promise in managing both short-term and long-term pain, but further studies are needed to confirm its effectiveness and safety.

Eligible Conditions
  • Anesthesia
  • Local Anesthesia
  • Acute Pain
  • Liver Resection

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-operative day 0, 1, 2, 3, 4, 14, 30
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-operative day 0, 1, 2, 3, 4, 14, 30 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Total opioid requirement postoperative day (POD) 1-3
Secondary study objectives
Discharge opioids and refills.
Hospital Length Of Stay
Nausea
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active TreatmentExperimental Treatment2 Interventions
This group will receive a continuous erector spinae block catheter followed by an infusion of ropivacaine 0.2% at 10ml automatic set bolus per 120 minutes with 2ml/hr continuous infusion (14mls total every 2 hours per catheter)
Group II: PlaceboPlacebo Group2 Interventions
This group will receive a superficially placed (taped to the surface) erector spinae block catheter with a ropivacaine 0.2% infusion at 0.1ml /hr
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Spinal Morphine
2023
Completed Phase 4
~170

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,157 Previous Clinical Trials
1,571,349 Total Patients Enrolled
Engy T Said, MDPrincipal InvestigatorUniversity of California, San Diego
~16 spots leftby Sep 2025
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