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Anti-bacterial

Doxycycline for Sexually Transmitted Diseases

Phase 4
Waitlist Available
Led By Colleen Kelley, MD, MPH
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* Assigned male sex or female sex at birth
* In good general health
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours after last dose (hour 24/day 1)
Awards & highlights

Summary

The goal of this project is to collect data regarding the concentrations of doxycycline in mucosal tissues after daily dosing for 7 days in people assigned male sex at birth (AMAB) and assigned female sex at birth (AFAB) to inform future studies of doxycycline to protect against bacterial sexually transmitted infections (STIs).

Eligible Conditions
  • Sexually Transmitted Diseases

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours after last dose (hour 24/day 1)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours after last dose (hour 24/day 1) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Doxycycline Concentration in Rectal Tissue
Doxycycline Concentration in Vaginal Tissue

Side effects data

From 2021 Phase 4 trial • 26 Patients • NCT04167085
4%
Sinus infection
4%
Metastatic lung cancer dx
4%
Blurred vision
4%
Foot infection
4%
Emesis
4%
Pneumonia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Doxycycline
Placebo

Trial Design

1Treatment groups
Experimental Treatment
Group I: DoxycyclineExperimental Treatment1 Intervention
Study participants taking 7 consecutive, daily doses of 100mg of Doxycycline.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxycycline
2008
Completed Phase 4
~2430

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,665 Previous Clinical Trials
2,575,065 Total Patients Enrolled
16 Trials studying Sexually Transmitted Diseases
10,722 Patients Enrolled for Sexually Transmitted Diseases
Centers for Disease Control and PreventionFED
879 Previous Clinical Trials
22,477,040 Total Patients Enrolled
20 Trials studying Sexually Transmitted Diseases
65,301 Patients Enrolled for Sexually Transmitted Diseases
Colleen Kelley, MD, MPHPrincipal InvestigatorEmory University
6 Previous Clinical Trials
711 Total Patients Enrolled
2 Trials studying Sexually Transmitted Diseases
60 Patients Enrolled for Sexually Transmitted Diseases
~13 spots leftby Sep 2025
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