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Antiplatelet Agent

Aspirin for Endometriosis

Phase 4
Recruiting
Research Sponsored by Penn State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 day
Awards & highlights

Summary

This trial will compare blood pressure, pain, and platelet activity in women with and without endometriosis during certain tests. Participants will take aspirin and/or placebo and undergo exercise, cold pressor tests, iontophoresis, and blood draw.

Who is the study for?
This trial is for women aged 18-45, with or without endometriosis. It's not suitable for those who are pregnant, breastfeeding, have a high BMI or certain health conditions like cardiovascular disease, diabetes, severe liver or kidney issues, hypertension/hypotension, Raynaud's syndrome; those on medications affecting blood pressure; smokers; recent hormone therapy users; and individuals with skin allergies.
What is being tested?
The study tests how aspirin affects blood pressure and pain in response to stress in women with endometriosis compared to healthy women. Participants will take aspirin or a placebo and undergo exercises and tests to measure neurovascular regulation differences between the two groups.
What are the potential side effects?
Aspirin may cause side effects such as stomach upset or bleeding risks. The placebo should have no active effects but can sometimes cause reactions due to expectations of treatment.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
blood pressure
heart rate
pain scale
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: AspirinExperimental Treatment1 Intervention
one dose of aspirin
Group II: PlaceboPlacebo Group1 Intervention
Placebo pill
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aspirin
2014
Completed Phase 4
~55580

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Who is running the clinical trial?

Penn State UniversityLead Sponsor
365 Previous Clinical Trials
127,604 Total Patients Enrolled
4 Trials studying Endometriosis
172 Patients Enrolled for Endometriosis
~64 spots leftby Aug 2026
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