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Antiplatelet agent

Ticagrelor Arm for Acute Coronary Syndrome (CPRS-CKD Trial)

Phase 4
Waitlist Available
Research Sponsored by North Texas Veterans Healthcare System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year from date of admission
Awards & highlights

Summary

To compare clinical outcomes in patients with chronic kidney disease (CKD) presenting with an acute coronary syndrome (ACS) treated with clopidogrel or ticagrelor (both FDA approved and guideline indicated drugs for treating these patients upstream managed medically or with coronary revascularization).

Eligible Conditions
  • Acute Coronary Syndrome
  • Chronic Kidney Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year from date of admission
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year from date of admission for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Occurrence of all-cause mortality, non-fatal myocardial infarction (MI), or ischemic stroke
Secondary study objectives
Length of hospital stay and readmission
Need for ischemia driven urgent coronary revascularization
Occurrence of MACE events
+1 more

Trial Design

2Treatment groups
Active Control
Group I: Ticagrelor ArmActive Control1 Intervention
Eligible patients randomized to the Ticagrelor arm will receive open label drug at a dose selected by their providers along with 81mg aspirin. These patients will be followed for 1 year through chart review for events. For event free patients, a phone follow-up will be done at the end of 1 year to record events These events be documented in the medical records.
Group II: ClopidogrelActive Control1 Intervention
Eligible patients randomized to the Clopidogrel arm will receive open label drug at a dose selected by their providers along with 81mg aspirin. These patients will be followed for 1 year through chart review for events. For event free patients, a phone follow-up will be done at the end of 1 year to record events These events be documented in the medical records

Find a Location

Who is running the clinical trial?

North Texas Veterans Healthcare SystemLead Sponsor
37 Previous Clinical Trials
4,005,009 Total Patients Enrolled
1 Trials studying Acute Coronary Syndrome
40 Patients Enrolled for Acute Coronary Syndrome
~26 spots leftby Sep 2025
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