← Back to Search

Other

Cervical Sympathetic Block for Cerebral Vasospasm

N/A
Waitlist Available
Led By Anna Maria Bombardieri, MD, PhD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients hospitalized in the ICU and developing cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Patients aged 18 and over
Must not have
Known advanced stage kidney disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up duration of recovery in icu (1-2 weeks)
Awards & highlights

Summary

This trial will assess if a cervical sympathetic block can improve cerebral blood flow & neurological function in people with aneurysm-related brain issues.

Who is the study for?
This trial is for adults over 18 who are in the ICU with cerebral vasospasm following a brain aneurysm bleed. It's not suitable for those with advanced kidney disease.
What is being tested?
The study tests whether a cervical sympathetic block, which is an injection near the neck to interrupt nerve signals, can improve blood flow in the brain and neurological recovery after a subarachnoid hemorrhage.
What are the potential side effects?
Potential side effects of cervical sympathetic block may include soreness or bruising at the injection site, temporary difficulty swallowing, hoarseness, and less commonly, drooping eyelid or pupil constriction.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am in the ICU due to brain vessel spasms after a brain bleed from an aneurysm.
Select...
I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
My kidney disease is in an advanced stage.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~duration of recovery in icu (1-2 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and duration of recovery in icu (1-2 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cerebral blood flow
Neurological function
Secondary study objectives
Cerebral blood flow velocity

Trial Design

1Treatment groups
Experimental Treatment
Group I: Cervical sympathetic blockExperimental Treatment1 Intervention
Patients hospitalized in the ICU and developing clinical manifestations of cerebral vasospasm will undergo a computerized tomography (CT) angiography and a CT perfusion scan. If the vasospasm will be confirmed by the CT imaging, a cervical sympathetic nerve block under ultrasound guidance will be performed. The block consists in the deposition of local anesthetic at the cervical sympathetic ganglion that will be visualized with an ultrasound device. A periganglionar catheter will be left in place. A CT angiography and CT perfusion will be repeated to check the effect of the block on the brain vasculature after the block is done. Patients will have a daily monitoring of their neurological function and of their cerebral blood flow with transcranial doppler in the ICU.

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,448 Previous Clinical Trials
17,492,384 Total Patients Enrolled
Anna Maria Bombardieri, MD, PhDPrincipal InvestigatorStanford University
1 Previous Clinical Trials
10 Total Patients Enrolled
~1 spots leftby Dec 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top