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Behavioral Activation for Anhedonia
N/A
Waitlist Available
Led By Christian A Webb, Ph.D.
Research Sponsored by Mclean Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Summary
This trial will test a therapy called Behavioral Activation (BA) on adolescents who have trouble feeling pleasure due to depression. BA helps by encouraging them to do more activities they enjoy, which can improve their mood. The study will see how well this therapy works and what changes occur in the brain and behavior. Behavioral Activation (BA) is a well-established treatment for depression that focuses on increasing engagement in enjoyable and meaningful activities to improve mood.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Trial Design
1Treatment groups
Experimental Treatment
Group I: Behavioral ActivationExperimental Treatment1 Intervention
12 weeks (1 50-min session per week) of Behavioral Activation for the anhedonic adolescents.
Behavioral Activation is a psychosocial treatment for depression focused on gradually re-engaging patients with sources of reinforcement and reward in their environment (e.g., increasing activites and interpersonal interactions). In contrast to Cognitive Behavioral Therapy, and as the name implies, Behavioral Activation focuses on behavioral strategies to improve mood and places little emphasis on cognitive restructuring techniques.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Behavioral Activation
2013
Completed Phase 3
~2940
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Who is running the clinical trial?
Mclean HospitalLead Sponsor
215 Previous Clinical Trials
21,613 Total Patients Enrolled
5 Trials studying Anhedonia
743 Patients Enrolled for Anhedonia
Christian A Webb, Ph.D.Principal InvestigatorMcLean Hospital & McLean Hospital
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You have used cocaine or other stimulant drugs in the past.You have taken drugs that affect dopamine, such as methylphenidate.You have had a head injury that made you lose consciousness.You have a history of seizures.You have a serious or unstable medical condition like heart, liver, kidney, lung, hormone, brain, or blood problems.You have had a diagnosed mental health or substance-related issue according to the DSM-5.You are a healthy adolescent who is not taking any psychiatric medications.You have signs of low thyroid function based on tests or symptoms.You have a medical or neurological condition that could affect the brain blood flow measurements taken during the study.You have a positive pregnancy test.Adolescents who have thoughts of hurting themselves and cannot receive outpatient behavioral activation treatment. They will be referred to the right clinical care immediately.You are currently getting medicine or talking to a therapist for feeling no pleasure in things you normally enjoy.You are a teenager with a close family member who has a history of mental health issues.You are right-handed.Adolescents with signs of feeling very sad or down during the phone screening.You have certain severe mental health conditions like schizophrenia, bipolar disorder, or severe substance use disorder. If you have less severe anxiety conditions, it's okay if they are caused by anhedonia.Adolescents who have had depression for more than 2 years.If you don't feel pleasure in things you used to enjoy, you may be eligible. If you're a healthy control, you shouldn't have any problems feeling pleasure.You haven't taken certain medications for a specific period of time before joining the study.
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