Popular Trials
Behavioural Intervention
iTBS for Concussion-Related Impulsivity and Suicidal Thoughts
This trial studies a new treatment for impulsivity, suicidal thoughts, and functional impairments after a mild traumatic brain injury. Researchers use a high-powered magnetic pulse, called iTBS, to activate certain cells in the brain to try and improve symptoms.
Non-invasive Brain Stimulation
rTMS for AUD+mTBI
This trial is testing whether a treatment called repetitive transcranial magnetic stimulation (rTMS) can help reduce alcohol craving in veterans with mild traumatic brain injury and/or post-traumatic stress disorder.
Behavioural Intervention
Pacing and Planning App for Traumatic Brain Injury
This trial tests the MyBrainPacerâ„¢ app, which helps people with post-concussion syndrome manage their daily activities using a point system. The app assigns points to activities based on how much energy they require and how severe the symptoms they might trigger. This helps users avoid overexertion and manage their symptoms more effectively.
Popular Filters
Trials for Post-Concussion Syndrome Patients
Procedure
Brain Stimulation + Cognitive Training for Mild Traumatic Brain Injury
This trial will test a new way to help improve attention in military personnel and veterans who have experienced mild traumatic brain injuries. The method involves using a brain stimulation technique called "Remotely Supervised Trans
Procedure
rTMS for Post-Concussion Syndrome
This trial studies how rTMS, a non-invasive brain stimulation technique, can help reduce chronic headaches from mild traumatic brain injury (mTBI). It aims to improve post-concussion symptoms & reduce costs of delayed recovery.
Behavioural Intervention
Active Rehabilitation for Post-Concussion Syndrome
It has been suggested that activity immediately following concussion is detrimental to recovery and may lead to long term impairments. The animal model has shown that exercise too soon can lead to neurometabolic energy imbalances within the brain. However, there is also evidence to suggest that prolonged inactivity has negative consequences that may contribute to prolongation of symptoms. Determining the ideal timeframe in which to initiate an active rehabilitation protocol for patients who are slow to recovery is an important factor in concussion management.
Procedure
Hyperbaric Oxygen for Traumatic Brain Injury
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of mild traumatic brain injury (mTBI).
Trials for Traumatic Brain Injury Patients
Procedure
Brain Stimulation + Cognitive Training for Mild Traumatic Brain Injury
This trial will test a new way to help improve attention in military personnel and veterans who have experienced mild traumatic brain injuries. The method involves using a brain stimulation technique called "Remotely Supervised Trans
Device
HS-1000 recording for Traumatic Brain Injury
The HS-1000 is an innovative non-invasive monitoring device that employs advanced acoustic signal analysis to calculate ICP on a continuous basis. Initial HS-1000 clinical data also shows promise in assessing a variety of cerebral hemodynamic parameters such as cerebral blood-flow, auto regulation monitoring, and cerebrovascular vessels compliance. In the absence of a non-invasive monitor of intracranial pressure (ICP), the relationships, if any, that may exist between concussion, timing of the concussion (e.g. acute, resolving, resolved) and ICP is unknown. The new HS-1000 non-invasive device may provide insight into assessment of possible ICP changes following concussion in children.
Trials With No Placebo
Behavioural Intervention
Mixed Reality Rehabilitation for Traumatic Brain Injury
This trial aims to test whether a new rehabilitation method called Praxis, which uses wearable sensors and a virtual reality environment, can help military service members with mild Traumatic Brain Injury (mTBI)
Behavioural Intervention
Problem-Solving Training for Concussion
This trial is testing a new treatment called PST-Concussion to help Veterans with mild traumatic brain injury manage their symptoms. The study aims to see if this treatment can reduce psychological distress and improve overall functioning. If successful, it could offer a practical way to support Veterans' recovery. Problem-solving treatment (PST) has been previously explored as a method to help service members with mild traumatic brain injury manage their symptoms.
Behavioral Intervention
Aerobic Exercise for Concussion
This trial aims to prove that starting personalized aerobic exercise early can help improve recovery from concussions, speed up return to duty, and reduce ongoing symptoms in military personnel. Additionally, the trial will look into
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Frequently Asked Questions
Introduction to concussion
What are the top hospitals conducting concussion research?
When it comes to advancing our understanding of concussions, several top hospitals across the United States are leading the way. In Pittsburgh, Pennsylvania, the University of Pittsburgh is at the forefront with three active concussion trials and a total of four trials conducted thus far. Since recording their first concussion trial in 2017, this hospital has been dedicated to investigating ways to improve diagnosis and treatment for this common brain injury. In Hines, Illinois, Edward Hines Jr. VA Hospital is also contributing significantly with three ongoing concussion trials and a history of four previous studies since their inaugural trial in 2019.
Meanwhile, Mayo Clinic in Rochester, Minnesota is making strides as well with its current involvement in three active concussion trials and two completed studies overall since initiating research efforts on this condition in 2019. On the West Coast at Naval Medical Center San Diego in California, researchers have been diligently working on concussions since their first recorded trial back in 2013. With two active clinical trials and a total of four conducted experiments in their arsenal, they continue to make valuable contributions towards improving patient outcomes.
Further expanding our knowledge on concussions is taking place at Milwaukee's Medical College of Wisconsin where researchers are actively engaged with two ongoing clinical trials while building upon four prior investigations dating back to 2015.
Across these esteemed institutions scattered throughout the country- from Pittsburgh to Hines; Rochester to San Diego; Milwaukee- medical professionals are focused on identifying better methods for diagnosing and treating concussions effectively.With every study they undertake or complete,it brings us closer towards enhancing care provision for those affected by these head injuries that can potentially impact lives both inside military services & civilian community.This collective effort demonstrates commitment towards improving quality-of-life post-concussion not only among service members but also athletes,falls victims,and anyone who may have experienced such incidents
Which are the best cities for concussion clinical trials?
When it comes to concussion clinical trials, several cities are at the forefront of research and development. Vancouver, British Columbia leads with 14 active trials exploring treatments like Cognitive Behavioural Therapy (CBT), Guideline implementation tools, and Graded Exposure Therapy. Calgary, Alberta follows closely behind with 10 ongoing studies focused on interventions such as rTMS, Symptom-specific Headache Treatment, and Melatonin 10mg. Toronto, Ontario also contributes significantly with 6 active trials investigating approaches like Graded Exposure Therapy and Newly designed computer monitors. Additionally, Seattle in Washington state and Pittsburgh in Pennsylvania each have 5 active trials examining various treatment options for concussions. These cities provide valuable opportunities for individuals affected by concussions to participate in groundbreaking clinical research aimed at improving outcomes and enhancing care strategies.
Which are the top treatments for concussion being explored in clinical trials?
Clinical trials are currently exploring several promising treatments for concussions. Among these, HS-1000 recording is leading the way with two active trials and a total of two concussion trials since its debut in 2015. Another noteworthy contender is tdcs in Youth with mild traumatic brain injury, which has embarked on one active trial and stands as the sole concussion trial listed thus far since its introduction in 2023. These innovative treatments offer hope for improved management and recovery from concussions, paving the way towards better outcomes for individuals affected by this condition.
What are the most recent clinical trials for concussion?
Exciting progress is being made in the field of concussion research, with recent clinical trials exploring novel approaches to treatment. One such trial focuses on active iTBS, a non-invasive brain stimulation technique that shows potential for aiding concussion recovery. Another study investigates active left frontal HD-tdcs, which targets specific areas of the brain to mitigate symptoms associated with concussions. Additionally, high-dose exercise has emerged as a promising intervention for individuals recovering from concussions. These advancements provide hope for improving outcomes and quality of life for those affected by this common injury.
What concussion clinical trials were recently completed?
Recent advancements in concussion research have seen the completion of several noteworthy clinical trials. In October 2020, a trial led by Michael Rippee, MD, investigated the potential benefits of Ghrelin (OXE-103) for individuals with concussions. Another significant study conducted by The University of Texas Health Science Center at San Antonio concluded in February 2019 and examined the use of Quetiapine Fumarate as a potential treatment for concussions. These completed trials represent important contributions to our understanding and management of this complex neurological condition.