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Behavioral Intervention

Positive Affect Treatment for Anxiety

N/A
Waitlist Available
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* English-speaking
* Low positive affect indexed by less than or equal to 24 on the positive affect subscale of the PANAS (i.e., PANAS-P); and scores of greater than or equal to 11 for depression, greater to or equal to 6 for anxiety, or greater to or equal to 10 for stress on the Depression, Anxiety, and Stress Scale; and scores of greater than or equal to 5 on any Sheehan Disability Scale subscale.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition)
Awards & highlights

Summary

The goal of this study is to determine whether subjects who do not show expected clinical improvement during the early course of positive affect treatment (PAT) would benefit from switching to an alternative psychosocial treatment (negative affect treatment) that is designed to instead target and improve deficits in threat sensitivity. Participants will complete laboratory tests, psychiatric assessments, and self-report questionnaires as part of the study. The total length of participation is around 5 months.

Who is the study for?
This trial is for individuals experiencing anxiety and depression who haven't improved with initial positive affect treatment. Participants will undergo lab tests, psychiatric assessments, and questionnaires over a 5-month period.
What is being tested?
The study is testing if switching from Positive Affect Treatment (PAT) to Negative Affect Treatment improves outcomes for those not responding well to PAT alone in treating anxiety and depression.
What are the potential side effects?
Potential side effects are not specified but may include discomfort or emotional distress due to the nature of psychological treatments and the conditions being addressed.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (week 1), pre-treatment (week 2), mid-treatment (week 6), post-treatment (week 11/week 16, depending on treatment condition) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Depression Anxiety and Stress Scale (DASS-21)
Positive and Negative Affect Schedule Expanded (PANAS-X) (General Dimensions Scales)
Secondary study objectives
Beck Depression Inventory (BDI-9)
Behavioral Inhibition/Behavioral Activation (reward drive subscale) (BAS-RD)
Dimensional Anhedonia Rating Scale (DARS)
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Positive Affect TreatmentExperimental Treatment1 Intervention
8 sessions of psychotherapy designed to augment reward anticipation, reward attainment, and reward learning.
Group II: Positive Affect Treatment and Negative Affect TreatmentActive Control1 Intervention
8 sessions of psychotherapy. 3-5 sessions of psychotherapy designed to augment reward anticipation, reward attainment, and reward learning. Remaining sessions of psychotherapy designed to decrease threat avoidance, threat appraisal and arousal.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Positive Affect Treatment
2019
N/A
~110

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,554 Previous Clinical Trials
10,270,939 Total Patients Enrolled
34 Trials studying Anxiety
38,196 Patients Enrolled for Anxiety
Southern Methodist UniversityOTHER
36 Previous Clinical Trials
6,097 Total Patients Enrolled
6 Trials studying Anxiety
931 Patients Enrolled for Anxiety
~50 spots leftby Mar 2025
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