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Music Therapy for Parkinson's Disease

N/A
Recruiting
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinical diagnosis of Parkinson's Disease following MDS Parkinson's disease criteria
Be older than 18 years old
Must not have
Participants who have gone through specific injuries/brain surgery (eg. an injury where a piece of metal lodged in the eye or orbit)
Participants with atypical Parkinsonism (eg. Progressive supranuclear palsy, multiple system atrophy, drug induced, etc.)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Summary

This trial will explore how music can decrease apathy in Parkinson's Disease patients, by looking at how it affects the brain. It may be a path to better treatment for PD patients.

Who is the study for?
This trial is for people with Parkinson's Disease who experience apathy. They must be clinically diagnosed following MDS criteria and have a MoCa score above 21, indicating no significant cognitive impairment. Those with moderate depression, other neurological issues, metal/medical implants, or recent tattoos/surgery are excluded.
What is being tested?
The study investigates how music listening might reduce apathy in Parkinson's patients compared to podcast listening. It aims to understand the brain mechanisms involved when PD patients listen to music as a potential non-pharmacological treatment for apathy.
What are the potential side effects?
Since this trial involves non-invasive interventions like music and podcast listening, there are minimal expected side effects. However, participants may experience emotional responses or fatigue from engaging in the activities.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with Parkinson's Disease.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had an injury or surgery on my brain, such as metal in my eye.
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I have a form of Parkinsonism that is not typical Parkinson's disease.
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I have a neurological condition like MS, stroke, or brain lesion.
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I have moderate depression according to Beck's test.
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I have had severe or multiple head injuries.
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I have epilepsy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Assessment of musical reward sensitivity after a 4-week washout period post-intervention - Barcelona Musical Reward Questionnaire (BMRQ)
Assessment of musical reward sensitivity before and after an 8-week audio-based intervention - Barcelona Musical Reward Questionnaire (BMRQ)
Change in fMRI representational similarity analysis at rest before and after an 8-week audio-based intervention
+17 more
Secondary study objectives
Clinical assessment for Quality of Life before and after an 8-week audio-based intervention - Quality of Life Scale (QOLS); observing if the intervention improves QoL measures
White and grey matter distribution
Other study objectives
Clinical assessment for depressive symptoms (not diagnostic) - Beck's Depression Inventory (BDI)
Clinical assessment for overall cognition - Montreal Cognitive Assessment (MoCA)
Clinical assessment of overall reward/pleasure sensitivity - Snaith-Hamilton Pleasure Scale (SHAPS)
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Parkinson's Disease with apathy - Podcast-listeningExperimental Treatment1 Intervention
Participants in this arm will receive a YouTube account app to use. Prior to the start of the intervention, a research team member will guide participants in this group in choosing a podcast that they "find rewarding or motivating".
Group II: Parkinson's Disease with apathy - Music-listeningExperimental Treatment1 Intervention
Participants in this arm will receive a YouTube account app to use. Prior to the start of the intervention, a research team member will guide participants in this group in constructing a playlist of music that they "find rewarding or motivating".

Find a Location

Who is running the clinical trial?

Northeastern UniversityOTHER
97 Previous Clinical Trials
70,822 Total Patients Enrolled
University of British ColumbiaLead Sponsor
1,451 Previous Clinical Trials
2,483,140 Total Patients Enrolled

Media Library

Parkinson's Disease with apathy - Music-listening Clinical Trial Eligibility Overview. Trial Name: NCT05505019 — N/A
Apathy Research Study Groups: Parkinson's Disease with apathy - Music-listening, Parkinson's Disease with apathy - Podcast-listening
Apathy Clinical Trial 2023: Parkinson's Disease with apathy - Music-listening Highlights & Side Effects. Trial Name: NCT05505019 — N/A
Parkinson's Disease with apathy - Music-listening 2023 Treatment Timeline for Medical Study. Trial Name: NCT05505019 — N/A
~14 spots leftby Sep 2025
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